The DOI matches its Crossref record.
Evaluation and comparisons of biodegradable substances as osteogenic agents
Abstract
This study compared the osteogenic potential and tissue compatibility of biodegradable copolymers--PLA/PGA--and a biodegradable ceramic--Ca3(PO4)2. These compounds were placed in experimentally created defects in rat tibias, both in combination and singly, and evaluated at 14, 28, and 42 days. The ceramic served as a format to result in uniform osteogenesis throughout the defect. The copolymer implants resulted in a more gradual bone formation, progressing slowly from the would peripheries. The ceramic and copolymer combination behaved little differently from the copolymer alone. All experimental materials were extremely tissue tolerant, with minimal inflammation and no foreign-body reactions.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“PLA-PGA copolymers used in bone repair applications have shown to be biocompatible, non-toxic and non-inflammatory”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Nelson et al., 1977
In the citing paper
“Many studies suggests that these polymers are sufficiently biocompatible”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Nelson et al. 1977
Citations
Cites
Still being checked.
Research works printed but not linked: 10
- Kulkarni, 1966, Polylactic Acid for Surgical Implants, Arch. Surg, 93, 839, 10.1001/archsurg.1966.01330050143023 · DOI
- Cutright, 1972, The Repair of Fractures of the Orbital Floor, Oral Surg, 33, 28, 10.1016/0030-4220(72)90204-6 · DOI
- Getter, 1972, A Biodegradable Intraosseous Appliance in the Treatment of Mandibular Fractures, J. Oral Surg, 30, 344
- Cutright, 1971, Tissue Reaction to the Biodegradable Polylactic Acid Suture, Oral Surg, 31, 134, 10.1016/0030-4220(71)90044-2 · DOI
- Bhaskar, 1971, Biodegradable Ceramic Implants in Bone, Oral Surg, 32, 336, 10.1016/0030-4220(71)90238-6 · DOI
- Selting, 1973, Structural Strength of the Interface Between Bone and Nondegradable Porous Ceramic Implants, J. Dent. Res, 52, 91, 10.1177/00220345730520014201 · DOI
- Cutright, 1972, Reaction of Bone to Tricalcium Phosphate Ceramic Pellets, Oral Surg, 33, 850, 10.1016/0030-4220(72)90457-4 · DOI
- Levin, 1975, A Comparison of Iliac Marrow and Biodedegradable Ceramic in Periodontal Defects, J. Biomed. Mater. Res, 9, 183, 10.1002/jbm.820090207 · DOI
- Levin, 1974, Healing of Periodontal Defects With Ceramic Implants, J. Clin. Periodontal, 1, 197, 10.1111/j.1600-051X.1974.tb01258.x · DOI
- Getter, 1972, Three Biodegradable Calcium Phosphate Slurry Implants in Bone, J. Oral Surg, 30, 263
Cited by
Sorted by citations
Biodegradable synthetic polymers for tissue engineering
CSIRO Molecular Science, B. 1., & Gunatillake, P. (2003) · European Cells and Materials · doi:10.22203/ecm.v005a01 · Cited by 1,765
“PLA-PGA copolymers used in bone repair applications have shown to be biocompatible, non-toxic and non-inflammatory (Nelson et al., 1977; Hollinger, 1983).”
BackgroundBiodegradable PEO/PLA block copolymers
Cohn, D., & Younes, H. (1988) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820221104 · Cited by 241
Metadata
- Authors
- Nelson, J. F., Stanford, H. G., & Cutright, D. E.
- Affiliations
- Walter Reed National Military Medical Center (US)
- Corresponding author
- Nelson, John F.
- Venue
- Oral Surgery, Oral Medicine, Oral Pathology
- Publisher
- Elsevier BV
- Published
- 1977-06
- Volume
- 43
- Issue
- 6
- Pages
- 836-843
- ISSN
- 0030-4220 (ISSN-L)
- OpenAlex
- W2018225860
- Cited by
- 80
- References
- 0
- Citations by year
- 2026: 1 · 2023: 2 · 2021: 1 · 2018: 2 · 2017: 3 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oral Surgery Oral Medicine Oral Pathology (publishedVersion)
- PubMed (publishedVersion)
- Defense Technical Information Center (DTIC) (submittedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
- Keywords
- biodegradable polymers, polylactic acid, polyglycolic acid, calcium phosphate ceramics, bone defects, bone regeneration, histocompatibility, foreign body reaction, inflammation, rat tibia
- MeSH terms
- Animals, Biocompatible Materials, Biodegradation, Environmental, Bone and Bones, Bone Regeneration, Calcium Phosphates, Ceramics, Drug Combinations, Lactates, Osteogenesis, Polyglycolic Acid, Polymers, Time Factors, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
