Diet selection and metabolic fuels in three models of diabetes mellitus
Abstract
Dietary self-selection and circulating metabolic fuels (glucose, free fatty acids, ketones) were examined in three forms of experimental diabetes mellitus in rats: pancreatectomy and streptozotocin treatment in adult and neonatal rats. Changes in diet selection resulting from insulin replacement also were examined. Differences were found in diet selection and circulating metabolic fuels between these types of diabetes. Mildly diabetic rats selected large amounts of fat while more severely diabetic rats primarily selected protein. Insulin treatment enhanced carbohydrate intake of diabetic rats and nearly normalized diet selection and circulating metabolic fuels. All diabetic groups exhibited severe glucose intolerance. These results support the observations of the beneficial effects of low-carbohydrate diets, question the generality of the use of high-fat diets, and suggest a more important role for high-protein diets in energy regulation in severely diabetic rats.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Animals tend to avoid carbohydrates when carbohydrate metabolism is defective or altered, particularly during states of diabetes.
“animals tend to avoid carbohydrates when carbohydrate metabolism is defective or altered, particularly during states of diabetes”
From FGF21 and the physiological regulation of macronutrient preference (2020) · cites this paper as [42]
The citation lists haven’t been fetched yet
References 26 · Cited by 23
- Authors
- Bartness, T. J., & Rowland, N. E.
- Affiliations
- University of Florida (US)
- Corresponding author
- Rowland, Neil E.
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 1983-10
- Volume
- 31
- Issue
- 4
- Pages
- 539-545
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W1995231550
- Cited by
- 23
- References
- 26
- Citations by year
- 2022: 1 · 2021: 1 · 2020: 1 · 2012: 1
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- diet selection, experimental diabetes, insulin replacement therapy, impaired glucose tolerance, free fatty acids, ketones, dietary fat intake, protein intake, carbohydrate intake, low-carbohydrate diet, high-fat diet, high-protein diet, energy regulation, pancreatic resection, streptozotocin, neonatal diabetes, rats
- MeSH terms
- Animals, Blood Glucose, Diabetes Mellitus, Experimental, Diet, Dietary Carbohydrates, Dietary Fats, Dietary Proteins, Energy Metabolism, Fatty Acids, Nonesterified, Food Preferences, Insulin, Ketones, Male, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
