Progestin-induced changes in play behaviour of the prepubertal rat
Abstract
The effects of neonatal exposure to medroxyprogesterone acetate on later play behaviour was studied. The experiments reported here indicate that animals of both sexes exposed to the hormone neonatally show lower levels of rough-and-tumble play in the prepubertal period. The effect is primarily one on play initiation: the organisation of play behaviour once initiated is not significantly affected, and the effect on play does not seem to be secondary to effects on some other behaviour. Several hypotheses are considered that might account for these findings.
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Neonatal progesterone administration increased play in both sexes.
“neonatal progesterone administration increased play in both sexes [15]”
From Sex-specific effects of neonatal progestin receptor antagonism on juvenile social play behavior in rats (2021) · cites this paper as [15]
Cites
Mother rats interact differently with male amd female offspring.
Moore, C. L., & Morelli, G. A. (1979) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077599 · Cited by 353 · see citing works
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Thor, D. H., & Holloway, W. R. (1986) · Behavioral Neuroscience · doi:10.1037/0735-7044.100.2.275 · Cited by 73 · see citing works
Blake, B. E., & McCoy, K. A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.021 · Cited by 20 · see citing works
Orsucci, I. C., Becker, K. D., Ham, J. R., Lee, J. D. A., Bowden, S. M., & Veenema, A. H. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.115080 · Cited by 3 · see citing works
Forbes-Lorman, R. M. (2021) · Behavioral and Brain Functions · doi:10.1186/s12993-021-00183-z · Cited by 1 · see citing works
- Authors
- Birke, L. I. A., & Sadler, D.
- Affiliations
- The Open University (GB)
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 1983-03
- Volume
- 30
- Issue
- 3
- Pages
- 341-347
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W2083848571
- Cited by
- 36
- References
- 1
- Citations by year
- 2025: 1 · 2024: 2 · 2021: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 1
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- medroxyprogesterone acetate, neonatal hormone exposure, progestins, rough-and-tumble play, play behavior, play initiation, prepubertal development, sex differences
- MeSH terms
- Animals, Animals, Newborn, Behavior, Animal, Female, Male, Medroxyprogesterone, Motor Activity, Pregnancy, Rats, Inbred Strains, Social Behavior, Medroxyprogesterone Acetate, Rats
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