Effects of adult or perinatal hormonal environment on ultradian rhythms in locomotor activity of laboratory LEW/Ztm rats
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Four experiments were performed with male and female rats of the inbred strain LEW/Ztm maintained under a light-dark schedule of 12:12 hours. The animals were subject to castration (GOX) or ovariectomy (OVX), estradiol 17 beta-implantation (E2-capsules), and perinatal hormonal treatments with testosterone propionate (TP) and an androgen antagonist (cyproterone acetate, CA). Results indicated a difference in the locomotor activity pattern between the two sexes as a result of the endogenous estradiol levels of the adult animals. The activity pattern of male LEW rats was characterized by ultradian rhythms of 4 and 4.8 hr periods. The female LEW rats, on the other hand, generally exhibited a clear circadian activity pattern and no ultradian activity rhythms. Following ovariectomy, each of the females showed distinct ultradian rhythms. These disappeared after E2-implantation. Castration of adult males had no effect on the ultradian activity pattern. Implantation of E2-capsules resulted in a marked decrease of the ultradian activity components. Perinatal treatment of the males with an androgen antagonist (CA) did not appear to effect ultradian rhythms during adulthood. Females treated perinatally with testosterone showed a significant increase in the ultradian activity components. This effect is assumed to be due to low estrogen levels in these animals during adulthood. Our study supports the assumption that ultradian rhythms are a result of changes in the phase relationships between several circadian oscillators. The synchrony of these oscillations seems to be facilitated by estradiol.
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Both androgens and estrogens can consolidate rhythms at the beginning of the active period in rodents.
“This conclusion is consistent with previous data indicating that both androgens and estrogens can consolidate rhythms at the beginning of the active period in rodents [78, 128, 187, 203]”
From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [203]
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References 55 · Cited by 39
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- Authors
- Wollnik, F., & Döhler, K.-D.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Corresponding author
- Wollnik, Franziska
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 1986-01
- Volume
- 38
- Issue
- 2
- Pages
- 229-240
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W2122567292
- Cited by
- 39
- References
- 55
- Citations by year
- 2026: 2 · 2023: 2 · 2022: 2 · 2020: 1 · 2019: 2 · 2013: 2 · 2012: 4
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- OPUS Publication Server of the University of Stuttgart (University of Stuttgart) (submittedVersion, other-oa)
- Universitätsbibliothek Stuttgart
- Funders
- Deutsche Forschungsgemeinschaft (SFB 146)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- ultradian rhythms, locomotor activity, estradiol, perinatal hormone exposure, castration, ovariectomy, testosterone propionate, cyproterone acetate, sex differences, circadian clock, circadian synchronization, androgen antagonists
- MeSH terms
- Activity Cycles, Animals, Circadian Rhythm, Cyproterone, Estradiol, Female, Male, Motor Activity, Orchiectomy, Ovariectomy, Rats, Inbred Lew, Sex Characteristics, Gonadal Steroid Hormones, Testosterone, Cyproterone Acetate, Rats
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