Resocialisation of isolation-reared rats does not alter their anxiogenic profile on the elevated X-maze model of anxiety
Abstract
Rats were reared from weaning either in isolation or in social groups for 30 days and their behaviour on the elevated X-maze was studied. Isolation-reared rats displayed an anxiogenic profile on the X-maze compared to socially reared controls. Resocialisation of isolation-reared rats for a further 30 days did not reverse this anxiogenic profile, and isolation of the socially reared rats for 30 days did not produce an anxiogenic behavioural profile, indicating that the differences observed may be a result of a permanent developmental change. The locomotor hyperactivity induced by isolation was specific to the rearing conditions. It remains to be determined what neurochemical events are involved in the sustained effects of rearing in isolation.
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Juvenile social isolation in rats increases anxiety- and depression-like behavior.
“increases anxiety- and depression-like behavior (Parker and Morinan, 1986; Wright et al., 1991; Arakawa, 2003; Leussis and Andersen, 2008; Lukkes et al., 2009; Cuesta et al., 2020)”
From Social play experience in juvenile rats is indispensable for appropriate socio-sexual behavior in adulthood in males but not females (2023) · cites this paper as Wright et al., 1991
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References 22 · Cited by 177
- Authors
- Wright, I. K., Upton, N., & Marsden, C. A.
- Affiliations
- University of Nottingham (GB)
- Queen's Medical Centre (GB)
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 1991-12
- Volume
- 50
- Issue
- 6
- Pages
- 1129-1132
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W2035934447
- Cited by
- 177
- References
- 22
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 8 · 2020: 3 · 2019: 4 · 2018: 5 · 2017: 9 · 2016: 4 · 2015: 9 · 2014: 7 · 2013: 6 · 2012: 7
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- social isolation, resocialisation, anxiety, locomotor hyperactivity, social rearing, rats
- MeSH terms
- Aging, Animals, Anxiety, Male, Motor Activity, Social Behavior, Social Isolation, Rats
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