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Apneusis and apnea after parabrachial or Kölliker-Fuse N. Lesion; Influence of wakefulness

Caille, Dominique, Vibert, J.-F., Hugelin, A.·1981·Respiration Physiology
DOI 10.1016/0034-5687(81)90051-7
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Abstract

Comparisons were made between the effects of bilateral lesions of either the nucleus parabrachialis medialis (NPBM) or the Kölliker-Fuse (KF) nuclei in bivagotomized, spinalized and immobilized cats. In a first group animals were electrolytically decerebrated; in a second group animals were locally anaesthetized and atraumatically restrained (semi-chronic encéphale isolé preparation). Lesions resulted in: (1) a marked increase in TI (apneusis); (2) 50--80% decrease in amplitude of the integrated phrenic discharge (IPD); (3) variable lengthening, of TE. Following KF lesion, effects were significantly larger on TE in the decerebrate group, and on TI in the encéphale isolé group. In the encéphale isolé group awakening reduced TE and TI and brought them close to their prelesion values following both NPBM and KF lesion; on the other hand light sleep induced by pentobarbital led to expiratory apnea after KF lesion and reduced IPD amplitude to zero after NPBM lesion. It is proposed that the onset, tonic drive and cut off of the I discharge are normally controlled by three differently weighted influences originating from NPBM, KF and reticular formation respectively.

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Research works printed but not linked: 27

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  6. Caille, 1981, Sensibilité régionale à l'anesthésie barbiturique légère et profonde de neurones à modulation respiratoire du tronc cérébral chez le chat, C.R. Acad. Sci. (Paris)
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Metadata

Authors
Caille, D., Vibert, J.-F., & Hugelin, A.
Venue
Respiration Physiology
Publisher
Elsevier BV
Published
1981-07
Volume
45
Issue
1
Pages
79-95
ISSN
0034-5687
DOI
10.1016/0034-5687(81)90051-7
Cited by
40
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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CoChat. (2026). Citation check: Apneusis and apnea after parabrachial or Kölliker-Fuse N. Lesion; Influence of wakefulness. https://app.cochat.ai/papers/10.1016/0034-5687(81)90051-7
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Caille, D., Vibert, J.-F., & Hugelin, A. (1981). Apneusis and apnea after parabrachial or Kölliker-Fuse N. Lesion; Influence of wakefulness. Respiration Physiology. https://doi.org/10.1016/0034-5687(81)90051-7