The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
The distribution of the sickle-cell trait in East Africa and elsewhere, and its apparent relationship to the incidence of subtertian malaria
Abstract
The incidence of the sickle-cell trait in indigenous East Africans from 35 different tribes is recorded. All the tribes coming from regions where malaria is hyperendemic have an incidence of more than 10 per cent. with the trait, whereas in the tribes coming from areas where malaria is epidemic or absent the incidence of the trait is less than 10 per cent. Other evidence is quoted which indicates that severity of malaria is a very important factor in determining the frequency of the sickle-cell gene. This fact can be correlated with the observation that persons with the sickle-cell trait have a considerable natural resistance to infection with Plasmodium falciparum. The incidence of the sickle-cell trait in any population appears to be the result of a balance between at least two factors: the severity of malaria, which will tend to increase the frequency of the trait, and the rate of elimination of sickle-cell genes in subjects dying of sickle-cell anaemia.
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Citations
Cites
Protection Afforded by Sickle-cell Trait Against Subtertian Malarial Infection
Allison, A. C. (1954) · BMJ · doi:10.1136/bmj.1.4857.290 · Cited by 1,291
Self-citationPeculiar elongated and sickle-shaped red blood corpuscles in a case of severe anemia. 1910.
Jb, H. (2001) · PubMed Central · Cited by 676
PECULIAR ELONGATED AND SICKLE-SHAPED RED BLOOD CORPUSCLES IN A CASE OF SEVERE ANEMIA
HERRICK, J. B. (1910) · Archives of Internal Medicine · doi:10.1001/archinte.1910.00050330050003 · Cited by 643
Daland, G. A., & Castle, W. B. (1948) · PubMed · Cited by 168
Emmel, V. E. (1917) · Archives of Internal Medicine · doi:10.1001/archinte.1917.00090040108005 · Cited by 99
Sickle cell disease in the Balovale District of Northern Rhodesia.
BEET, E. A. (1946) · PubMed · Cited by 75
Sickle cell disease in Northern Rhodesia.
BEET, E. A. (1947) · PubMed · Cited by 41
Analytical Review: Perspectives in the Genetics of Sickle Cell Disease
Neel, J. V. (1952) · Blood · doi:10.1182/blood.v7.4.467.467 · Cited by 28
SICKLE-CELL TRAIT AND BLOOD-GROUPS IN GREECE
Choremis, C., Ikin, E. W., Lehmann, H., Mourant, A. E., & ZANNOS, L. (1953) · The Lancet · doi:10.1016/s0140-6736(53)90567-4 · Cited by 23
The sickle cell trait; its clinical significance.
Brain, P. (1952) · PubMed · Cited by 22
Cited by
Psychological universals: what are they and how can we know?
Norenzayan, A., & Heine, S. J. (2005) · Psychological Bulletin · doi:10.1037/0033-2909.131.5.763 · Cited by 820
EVOLUTION FROM FISH TO MAMMALS BY GENE DUPLICATION
OHNO, S., WOLF, U., & ATKIN, N. B. (2009) · Hereditas · doi:10.1111/j.1601-5223.1968.tb02169.x · Cited by 709
Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis
Piel, F. B., Patil, A. P., Howes, R. E., Nyangiri, O. A., Gething, P. W., Williams, T. N., Weatherall, D. J., & Hay, S. I. (2010) · Nature Communications · doi:10.1038/ncomms1104 · Cited by 629
“At the same time, a similar relationship between HbS and malaria was independently discovered in Afric”
High frequencies of α-thalassaemia are the result of natural selection by malaria
Flint, J., Hill, A. V. S., Bowden, D. K., Oppenheimer, S. J., Sill, P. R., Serjeantson, S. W., Bana-Koiri, J., Bhatia, K., Alpers, M. P., Boyce, A. J., et al. (1986) · Nature · doi:10.1038/321744a0 · Cited by 425
Metadata
- Authors
- Allison, A. C.
- Venue
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publisher
- Oxford University Press (OUP)
- Published
- 1954-07
- Volume
- 48
- Issue
- 4
- Pages
- 312-318
- ISSN
- 0035-9203 (ISSN-L)
- OpenAlex
- W2091903891
- Cited by
- 329
- References
- 13
- FWCI
- 27.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The distribution of the sickle-cell trait in East Africa and elsewhere, and its apparent relationship to the incidence of subtertian malaria. https://app.cochat.ai/papers/10.1016/0035-9203(54)90101-7
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- Allison, A. C. (1954). The distribution of the sickle-cell trait in East Africa and elsewhere, and its apparent relationship to the incidence of subtertian malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene. https://doi.org/10.1016/0035-9203(54)90101-7
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
