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The antimalarial action on Plasmodium falciparum of qinghaosu and artesunate in combination with agents which modulate oxidant stress
Abstract
The antimalarial activity of qinghaosu (artemisinine) against Plasmodium falciparum in culture was enhanced by increased oxygen tension. Artesunate, a qinghaosu derivative, showed synergistic effects with miconazole, and with doxorubicin, both of which have been suggested to exert their chemotherapeutic effect through increasing the oxidant stress. In contrast, catalase, dithiothreitol and alpha-tocopherol reduced the effectiveness of qinghaosu in vitro. These results suggest that the action of qinghaosu and artesunate might involve increase in oxidant stress on the infected red cells.
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Citations
Cited by
A Medicinal Chemistry Perspective on Artemisinin and Related Endoperoxides
O'Neill, P. M., & Posner, G. H. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm030571c · Cited by 538
Discovery, mechanisms of action and combination therapy of artemisinin
Cui, L., & Su, X.-Z. (2009) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.09.68 · Cited by 371
Percário, S., Moreira, D., Gomes, B., Ferreira, M., Gonçalves, A., Laurindo, P., Vilhena, T., Dolabela, M., & Green, M. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131216346 · Cited by 363
Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu)
Meshnick, S. R., Yang, Y. Z., Lima, V, Kuypers, F., Kamchonwongpaisan, S., & Yuthavong, Y. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.5.1108 · Cited by 327
Self-citationYeast Model Uncovers Dual Roles of Mitochondria in the Action of Artemisinin
Li, W., Mo, W., Shen, D., Sun, L., Wang, J., Lu, S., Gitschier, J. M., & Zhou, B. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010036 · Cited by 304
Metadata
- Authors
- Krungkrai, S. R., & Yuthavong, Y.
- Venue
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publisher
- Oxford University Press (OUP)
- Published
- 1987-09
- Volume
- 81
- Issue
- 5
- Pages
- 710-714
- ISSN
- 0035-9203 (ISSN-L)
- OpenAlex
- W1978281757
- Cited by
- 176
- References
- 0
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The antimalarial action on Plasmodium falciparum of qinghaosu and artesunate in combination with agents which modulate oxidant stress. https://app.cochat.ai/papers/10.1016/0035-9203(87)90003-4
- The paper
- Krungkrai, S. R., & Yuthavong, Y. (1987). The antimalarial action on Plasmodium falciparum of qinghaosu and artesunate in combination with agents which modulate oxidant stress. Transactions of the Royal Society of Tropical Medicine and Hygiene. https://doi.org/10.1016/0035-9203(87)90003-4
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
