Albendazole in hydatid disease—hepatocellular toxicity
Abstract
D.L. Morris, P.G. Smith; Albendazole in hydatid disease—hepatocellular toxicity, Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume
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Most problems with albendazole are associated with higher dose treatment for systemic infections where drug-parasite interactions cause specific syndromes such as abnormal liver functions, central nervous system symptoms, or hematologic side effects.
“Most problems are associated with higher dose treatment for systemic infections where problems of drug-parasite interactions cause specific syndromes such as abnormal liver functions (for example, in echinococcosis), central nervous system symptoms (in neurocysticercosis), or hematologic side effects [53,308–312].”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [308]
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Albendazole in treatment of human cystic echinococcosis: 12 years of experience.
Horton, R. J. (1997) · Acta Tropica · doi:10.1016/s0001-706x(96)00640-7 · Cited by 292 · see citing works
Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
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Control strategies for human intestinal nematode infections.
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Chemotherapy of Echinococcus infection in man with albendazole.
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Diagnosis and treatment of human hydatidosis.
Wen, H., New, R. R., & Craig, P. (1993) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1993.tb04182.x · Cited by 148
“Albendazole was found to be hepatotoxic but transaminase abnormalities have been shown to be reversible (Morris & Smith, 1987a; Wilson et al., 1987).”
BackgroundPre‐operative albendazole therapy for hydatid cyst
Morris, D. (1987) · British Journal of Surgery · doi:10.1002/bjs.1800740918 · Cited by 136
Self-citationThe Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs
Son, D.-S., Lee, E.-S., & Adunyah, S. E. (2020) · Immune Network · doi:10.4110/in.2020.20.e29 · Cited by 130 · see citing works
“Although albendazole has hepatotoxicity, liver function in patients recovered rapidly on the withdrawal of albendazole (113).”
BackgroundRenal echinococcosis: clinical study of 34 cases.
Angulo, J., Sánchez-chapado, M., Diego, A., Escribano, J., Tamayo, J., & Martin, L. (1997) · Journal of Urology · doi:10.1016/s0022-5347(01)65041-9 · Cited by 122
Albendazole for the treatment of echinococcosis
John, H. (2003) · Fundamental & Clinical Pharmacology · doi:10.1046/j.1472-8206.2003.00171.x · Cited by 116 · see citing works
Radical Surgical Therapy of Abdominal Cystic Hydatid Disease: Factors of Recurrence
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“However, in the hands of an experienced surgeon, such operations can be carried out with a low complication rate [2, 5, 9, 13].”
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“Mild: alopecia, self-limiting, up to 5-fold increase in liver enzymes, rash, abdominal pain (experienced during ABZ intake), gastrointestinal symptoms such as nausea and vomiting (experienced during ABZ intake), and headache; severe: bone marrow suppression and liver damage [22,23].”
BackgroundAlbendazole therapy of hydatid disease: 2-year follow-up of 40 cases.
el-Mufti, M., Kamag, A., Ibrahim, H., Taktuk, S., Swaisi, I., Zaidan, A., Sameen, A., Shimbish, F., Bouzghaiba, W., Haasi, S., et al. (1993) · Annals of Tropical Medicine and Parasitology · doi:10.1080/00034983.1993.11812762 · Cited by 55
Acute Drug-Induced Hepatitis Caused by Albendazole
Choi, G. Y., Yang, H. W., Cho, S. H., Kang, D. W., Go, H., Lee, W. C., Lee, Y. J., Jung, S. H., Kim, A. N., & Cha, S. W. (2008) · Journal of Korean Medical Science · doi:10.3346/jkms.2008.23.5.903 · Cited by 54 · see citing works
“Six of these patients had the hepatocellular type of abnormality and one developed an obstructive jaundice (9).”
BackgroundEchinococcosis (Hydatid disease): lessons from experience with 59 patients.
Schaefer, J. W., & Khan, M. Y. (1991) · Reviews of Infectious Diseases · doi:10.1093/clinids/13.2.243 · Cited by 43
“Hepatic toxicity [8] and bone marrow suppression are reported to be infrequent, and both respond to discontinuation of the drug.”
BackgroundFirst case of ivermectin-induced severe hepatitis.
Veit, O., Beck, B., Steuerwald, M., & Hatz, C. (2006) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/j.trstmh.2006.02.003 · Cited by 38 · see citing works
“There are a few cases of drug-induced hepatitis in the literature (Morris and Smith, 1987).”
BackgroundCombination chemotherapy of Echinococcus granulosus--in vitro studies.
Taylor, D., Morris, D. L., & Richards, K. (1988) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(88)90442-7 · Cited by 30
Self-citationAlbendazole Treatment of Hydatid Disease—Follow-Up at 5 Years
Morris, D. L. (1989) · Tropical doctor · doi:10.1177/004947558901900413 · Cited by 27
Self-citationMorris, D. L. (1994) · Gut · doi:10.1136/gut.35.11.1517 · Cited by 23
Self-citationHenke, K., Ntovas, S., Xourgia, E., Exadaktylos, A. K., Klukowska‐Rötzler, J., & Ziaka, M. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20216972 · Cited by 27 · see citing works
“It should be noted, however, that in predisposed individuals, even therapeutic doses of ABZ may cause liver toxicity in both adults and children [251–256].”
BackgroundAlbendazole-induced associated acute hepatitis and bicytopenia
Ben Fredj, N., Chaabane, A., Chadly, Z., Ben Fadhel, N., Boughattas, N. A., & Aouam, K. (2014) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365548.2013.835068 · Cited by 22 · see citing works
Morris, D. L., Richards, K., Clarkson, M., & Taylor, D. (1990) · Veterinary parasitology · doi:10.1016/0304-4017(90)90096-t · Cited by 22
Self-citationHydatid cyst associated with pregnancy: A case report and review of the literature.
Abu-Eshy, S., & Ali, M. E. (1999) · Annals of Saudi Medicine · doi:10.5144/0256-4947.1999.130 · Cited by 19
CASE REPORT: Complete Treatment of Ruptured Hepatic Cyst into Biliary Tree by ERCP
Hilmioğlu, F., Karıncaoğlu, M., Yılmaz, S., Yildirim, B., Kırımlıoğlu, V., Aladağ, M., & Onmuş, H. (2001) · Digestive Diseases and Sciences · doi:10.1023/a:1005670325782 · Cited by 14
“Furthemore, these medicines are hepatotoxic ( 19 ), and liver enzymes were not normal in our patient case.”
BackgroundAlbendazole-induced toxic hepatitis: A case report.
Gözüküçük, R., Abci, I., & Güçlü, M. (2009) · The Turkish Journal of Gastroenterology · doi:10.4318/tjg.2013.0426 · Cited by 8
Albendazole in hydatid disease: Results in 22 patients.
Yasawy, M. I., Mohamed, A. R. E. S., & Al-Karawi, M. (1992) · Annals of Saudi Medicine · doi:10.5144/0256-4947.1992.152 · Cited by 8
The Management of Hydatid Disease of the Liver: Part 1
Fenton-Lee, D., & Morris, D. L. (1996) · Tropical doctor · doi:10.1177/004947559602600413 · Cited by 7
Self-citationSubfulminant Acute Liver Failure by Albendazole: Case Report
Freire, J., Carolina, L., Lima, L. G., & Raposo, P. (2015) · doi:10.14740/jmc.v6i8.2147 · Cited by 5
“The diagnostic scale of the Council for International Organizations of Medical Sciences (CIOMS), also known as the causal Assessment Method or RUCAM, although complex and difficult to apply by doctors who are unfamiliar with induced liver injury by drugs, is often used by hepatologists [13].”
BackgroundTreatment of experimental alveolar echinococcosis with albendazole: a 1H NMR spectroscopic study
Modha, A., Novak, M., & Blackburn, B. (1997) · doi:10.1139/z97-027 · Cited by 5
“Effect of ABZ on the liver ABZ has been shown to have toxic effects on the liver, as shown by the enzymatic abnormalities detected by LFTs (Morris and Smith 1987), which in a nonspecific way suggest biliary obstruction and (or) hepatocellular damage (Andreoli et al.”
BackgroundResultInfluentialRecurrent albendazole-induced acute hepatitis
Narciso-Schiavon, J. L., Delziovo, H. A., Santos, L. E. B., Shiozawa, M. B. C., & Schiavon, L. L. (2018) · Revista Colombiana de Gastroenterología · doi:10.22516/25007440.206 · Cited by 4 · see citing works
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“In another series, liver transaminase concentrations rose in 6 out of 40 patients treated with this regimen but normalized on stopping therapy (Morris and Smith, 1987).”
BackgroundHydatid Disease of the Liver: Clinical Presentation and Complications
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(2022) · CABI Compendium · doi:10.1079/cabicompendium.97819
Sarli, L., Costi, R., Kayaalp, C., Bostanoğlu, A., Atalay, F., Akoǧlu, M., Gollackner, B., Rockenschaub, S., Steininger, R., Längle, F., et al. (2001) · World Journal of Surgery · doi:10.1007/s002680020155
- Authors
- Morris, D. L., & Smith, P. G.
- Affiliations
- Nottingham University Hospitals NHS Trust (GB)
- ORCID
- Morris, D.L.
- Venue
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publisher
- Oxford University Press (OUP)
- Published
- 1987-01
- Volume
- 81
- Issue
- 2
- Pages
- 343-344
- ISSN
- 0035-9203 (ISSN-L)
- OpenAlex
- W1975232315
- Cited by
- 54
- References
- 0
- Citations by year
- 2026: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Transactions of the Royal Society of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Parasitic infections in humans and animals
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Keywords
- albendazole, echinococcosis, drug-induced liver injury
- MeSH terms
- Aged, Aged, 80 and over, Anthelmintics, Benzimidazoles, Echinococcosis, Humans, Liver Function Tests, Male, Middle Aged, Albendazole, Chemical and Drug Induced Liver Injury
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