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Albendazole treatment of human cystic echinococcosis
Abstract
The effect of albendazole was investigated in 20 patients with single or multiorgan hydatid cyst disease. Albendazole was used at a dose of 10 mg/kg daily in cycles of 28 d for four cycles with 15 d between cycles. Follow-up ranged from 12-18 months. Response varied according to the organ involved, the most successful results being with liver and peritoneal cysts. A positive response was seen in 47% of 34 cyst sites and a partial response was seen in a further 38% of sites. Overall response was classed as completely successful in 30% of patients, and partially successful in 60% at the end of follow-up. Adverse events were rare, although occasional abnormalities of liver function were seen.
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Most problems with albendazole are associated with higher dose treatment for systemic infections where drug-parasite interactions cause specific syndromes such as abnormal liver functions, central nervous system symptoms, or hematologic side effects.
“Most problems are associated with higher dose treatment for systemic infections where problems of drug-parasite interactions cause specific syndromes such as abnormal liver functions (for example, in echinococcosis), central nervous system symptoms (in neurocysticercosis), or hematologic side effects [53,308–312].”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [309]
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Research works printed but not linked: 8
- Ghilevich, 1980, Recurrence of hydatid disease, Vestnik Khirurgii, 124, 39
- Kammerer, 1984, Long-term follow-up of human hydatid disease (Echinococcus granulosus) treated with a high-dose mebendazole regimen, American Journal of Tropical Medicine and Hygiene, 33, 132, 10.4269/ajtmh.1984.33.132 · DOI
- Morris, 1985, Albendazole-objective evidence of response in human hydatid disease, Journal of the American Medical Association, 253, 2053, 10.1001/jama.253.14.2053 · DOI
- Mottaghian, 1978, Postoperative recurrence of hydatid disease, British Journal of Surgery, 65, 237, 10.1002/bjs.1800650407 · DOI
- Quilici, 1976, Les modalités de constitution des “récidives” postopéeratoires de l'echinococcose à Echinococcus granulosus, Médecine et Maladies Infectieuses, 6, 12, 10.1016/S0399-077X(76)80031-5 · DOI
- Saimot, 1983, Albendazole as a potential treatment for human hydatidosis, Lancet, ii, 652, 10.1016/S0140-6736(83)92533-3 · DOI
- Todorov, 1984, Immunantwort bei sekundarer rezidivierender Echinokokkose des Menschen, vol. 16, 381
- Todorov, 1988, Albendazole treatment of multiple cerebral cysts: case report, Transactions of the Royal Society of Tropical Medicine and Hygiene, 82, 150, 10.1016/0035-9203(88)90291-X · DOI
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Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
Chai, J.-Y., Jung, B.-K., & Hong, S.-J. (2021) · The Korean Journal of Parasitology · doi:10.3347/kjp.2021.59.3.189 · Cited by 286
Metadata
- Authors
- Todorov, T., Vutova, K., Petkov, D., Mechkov, G., & Kolev, K.
- Affiliations
- Military Medical Academy (BG)
- Venue
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publisher
- Oxford University Press (OUP)
- Published
- 1988-05
- Volume
- 82
- Issue
- 3
- Pages
- 453-459
- ISSN
- 0035-9203 (ISSN-L)
- OpenAlex
- W2099476782
- Cited by
- 34
- References
- 0
- Citations by year
- 2025: 1 · 2021: 1 · 2018: 1 · 2015: 1 · 2013: 2
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Transactions of the Royal Society of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasitic infections in humans and animals
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Life Sciences › Immunology and Microbiology › Parasitology › Parasitic Infections and Diagnostics
- Keywords
- albendazole, echinococcosis, Echinococcus granulosus, antiparasitic treatment, liver cysts, peritoneal cysts, treatment response, adverse events, liver dysfunction
- MeSH terms
- Adult, Anthelmintics, Benzimidazoles, Echinococcosis, Echinococcosis, Hepatic, Female, Humans, Liver, Male, Middle Aged, Tomography, X-Ray Computed, Albendazole
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