Albendazole for the treatment of human gnathostomiasis
Abstract
The efficacy of albendazole was investigated in 112 patients with symptomatic gnathostomiasis; 49 received 400 mg twice daily, 51 received 400 mg once daily, and 12 patients received placebo, all for 21 d. Subsequent follow-up was for 6 months. Cure (no further swelling) was seen in 93.9% and 94.1% of the treatment groups but in none of the placebo group. Additionally, reductions in eosinophil counts and in immunoglobulin G antibody were observed after treatment. Side effects were minimal. Albendazole may be an effective compound for the treatment of gnathostomiasis.
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Albendazole (400-800 mg daily for 21 days) achieved 93.9-94.1% cure rate in 100 gnathostomiasis patients in Thailand.
“its usefulness (400–800 mg daily for 21 days) was confirmed with 93.9–94.1% CR in 100 gnathostomiasis patients in Thailand [133]”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [133]
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Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
Chai, J.-Y., Jung, B.-K., & Hong, S.-J. (2021) · The Korean Journal of Parasitology · doi:10.3347/kjp.2021.59.3.189 · Cited by 286 · see citing works
McCarthy, J., & Moore, T. A. (2000) · International Journal for Parasitology · doi:10.1016/s0020-7519(00)00122-3 · Cited by 254 · see citing works
- Authors
- Kraivichian, P., Kulkumthorn, M., Yingyourd, P., Akarabovorn, P., & Paireepai, C.-C.
- Affiliations
- Chulalongkorn University (TH)
- Venue
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publisher
- Oxford University Press (OUP)
- Published
- 1992-07
- Volume
- 86
- Issue
- 4
- Pages
- 418-421
- ISSN
- 0035-9203 (ISSN-L)
- OpenAlex
- W2031766595
- Cited by
- 106
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 3 · 2017: 1 · 2016: 2 · 2015: 8 · 2014: 1 · 2013: 4 · 2012: 4
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Transactions of the Royal Society of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Life Sciences › Agricultural and Biological Sciences › Insect Science › Mollusks and Parasites Studies
- Keywords
- albendazole, gnathostomiasis, Gnathostoma, anthelmintic treatment, cure rate, eosinophil count, immunoglobulin G antibodies, adverse drug reactions, dosing regimen
- MeSH terms
- Adolescent, Adult, Aged, Animals, Antiparasitic Agents, Enzyme-Linked Immunosorbent Assay, Female, Gnathostoma, Humans, Male, Middle Aged, Nematode Infections, Recurrence, Skin, Albendazole, Treatment Outcome
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