Circulating concentrations of di(2-ethylhexyl) phthalate and its de-esterified phthalic acid products following plasticizer exposure in patients receiving hemodialysis
Abstract
The degree of exposure to the plasticizer di(2-ethylhexyl) phthalate (DEHP) was assessed in 11 patients undergoing maintenance hemodialysis for the treatment of renal failure. The amount of DEHP leached from the dialyzer during a 4-hr dialysis session was estimated by monitoring the DEHP blood concentration gradient across the dialyzer. Circulating concentrations of the biologically active products of DEHP de-esterification, viz., mono(2-ethylhexyl) phthalate (MEHP) and phthalic acid, were also determined during the dialysis session. On the average, an estimated 105 mg of DEHP was extracted from the dialyzer during a single dialysis session, with a range of 23.8 to 360 mg. The rate of extraction of DEHP from the dialyzer was correlated with serum lipid content as expressed by the sum of serum cholesterol and triglyceride concentrations (r = +0.65, p less than 0.05). Time-averaged circulating concentrations of MEHP during dialysis (1.33 +/- 0.58 micrograms/ml) were similar to those of DEHP (1.91 +/- 2.11 micrograms/ml). Blood concentrations of phthalic acid (5.22 +/- 3.94 micrograms/ml) were higher than those of the esters. The length of time patients had been receiving regular dialysis treatment was not a determinant of circulating concentrations of DEHP or MEHP. In contrast, time-averaged circulating concentrations of phthalic acid correlated strongly with the duration (in years) of dialysis treatment (r = +0.92, p less than 0.001). The results indicated substantial exposure…
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In serum of dialysis patients, phthalate acid (PA) was found as a metabolite of phthalates at remarkably high concentrations of 5.22 ± 3.94 mg/L.
“In the serum of patients who were undergoing dialysis [53,154,155,156], phthalate acid (PA) was found as a metabolite of phthalates at remarkably high concentrations of 5.22 ± 3.94 mg/L [155].”
From A Review of Biomonitoring of Phthalate Exposures (2019) · cites this paper as [155]
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A Review of Biomonitoring of Phthalate Exposures
Wang, Y., Zhu, H., & Kannan, K. (2019) · Toxics · doi:10.3390/toxics7020021 · Cited by 755 · see citing works
- Authors
- Pollack, G. M., Buchanan, J. F., Slaughter, R. L., Kohli, R. K., & Shen, D. D.
- Affiliations
- State University of New York (US)
- Corresponding author
- Shen, Danny D.
- ORCID
- Shen, Danny D.
- Venue
- Toxicology and Applied Pharmacology
- Publisher
- Elsevier BV
- Published
- 1985-06
- Volume
- 79
- Issue
- 2
- Pages
- 257-267
- ISSN
- 0041-008X (ISSN-L)
- OpenAlex
- W2034109514
- Cited by
- 116
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 1 · 2012: 3
- FWCI
- 6.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology and Applied Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-25797)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Physical Sciences › Materials Science › Polymers and Plastics › Polymer Science and PVC
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- DEHP, plasticizer exposure, hemodialysis, mono(2-ethylhexyl) phthalate, phthalic acid, serum lipids, serum cholesterol, serum triglycerides, chronic kidney disease, dialysis duration
- MeSH terms
- Adult, Aged, Cholesterol, Chromatography, High Pressure Liquid, Diethylhexyl Phthalate, Hematocrit, Renal Dialysis, Humans, Kidney Failure, Chronic, Middle Aged, Orosomucoid, Phthalic Acids, Triglycerides
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