The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Effects of adsorption of benzo[a]pyrene onto carbon black particles on levels of DNA adducts in lungs of rats exposed by inhalation
Abstract
Exposure of rodents to benzo[a]pyrene (BaP) associated with particles has previously been shown to result in increased retention of BaP and metabolites in lungs. To determine if DNA damage might be enhanced, DNA adducts were measured in lungs of F344 rats following inhalation of pure BaP aerosols or BaP absorbed on carbon black particles. Groups of rats were exposed nose only to filtered air, [14C]BaP (2 mg/m3), or [14C]BaP (2 mg/m3) adsorbed on carbon black (97 mg/m3) (BaP/CB) for 4 hr/day, 1 day/week, for 12 weeks. Groups of rats were terminated at 4, 8, 12, 16, 20, and 24 weeks after the beginning of the 12-week exposure period. Retention of total 14C in lungs was used as an indicator of total reactive metabolites. DNA isolated from lungs was analyzed for adducts using a 32P-postlabeling assay. Inhalation of BaP/CB resulted in 100-fold higher levels of 14C in lungs at the end of the 12-week exposure than did inhalation of pure BaP. The halftime for the decline in 14C levels was 34 +/- 3 weeks (mean +/- SE) for rats exposed to BaP/CB and 6 +/- 2 weeks for rats exposed to pure BaP. At the end of 12 weeks of exposure, DNA adducts in lungs of rats exposed to pure BaP ranged from 2-15 adducts per 10(9) bases (mean = 7, n = 4) and in rats exposed to pure BaP absorbed on carbon black ranged from 10-12 adducts per 10(9) bases (mean = 11, n = 4); DNA adducts in lungs of sham-exposed rats ranged from 0-2 adducts per 10(9) bases (mean = 1, n = 4). The halftimes for the decline in DNA adducts in lungs were 3 +/- 1 weeks (mean +/- SE) for the rats exposed to BaP/CB and 5 +/- 2 weeks for the rats exposed to BaP. One of the DNA adducts found following exposure to both BaP and BaP/CB was tentatively identified as the BaP diol epoxide deoxyguanosine (BPDE) adduct. Levels of both total and BPDE DNA adducts were significantly increased (p less than 0.05) in lungs of rats exposed to both BaP and BaP/CB compared to levels in lungs of sham-exposed rats. There were no significant differences in levels of DNA adducts in lungs of rats exposed to BaP or BaP/CB, although the pattern of adducts was different between the two exposure modes.(ABSTRACT TRUNCATED AT 400 WORDS)
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“PAHs penetrate into the epidermis easily (8–10) and are stable for 3~6 weeks in vivo (76).”
From Particulate matter causes skin barrier dysfunction. (2021) · cites this paper as [76]
Citations
Cites
Reddy, M. V., & Randerath, K. (1986) · Carcinogenesis · doi:10.1093/carcin/7.9.1543 · Cited by 1,009
32P-postlabeling analysis of non-radioactive aromatic carcinogen — DNA adducts
Gupta, R. C., Reddy, M. V., & Randerath, K. (1982) · Carcinogenesis · doi:10.1093/carcin/3.9.1081 · Cited by 652
Diesel exhaust is a pulmonary carcinogen in rats exposed chronically by inhalation
Mauderly, J. L. (1987) · Fundamental and Applied Toxicology · doi:10.1016/0272-0590(87)90044-3 · Cited by 258
Self-citationReddy, M. V., Gupta, R. C., Randerath, E., et al. (1984) · Carcinogenesis · doi:10.1093/carcin/5.2.231 · Cited by 230
Use of bronchoalveolar lavage to detect lung damage.
Henderson, R. F. (1984) · Environmental Health Perspectives · doi:10.1289/ehp.8456115 · Cited by 179
Self-citationJennette, K. W., Jeffrey, A. M., Blobstein, S. H., et al. (1977) · Biochemistry · doi:10.1021/bi00624a019 · Cited by 169
Perera, F. P., Poirier, M. C., Yuspa, S. H., et al. (1982) · Carcinogenesis · doi:10.1093/carcin/3.12.1405 · Cited by 167
Randerath, K., Reddy, M. V., & Disher, R. M. (1986) · Carcinogenesis · doi:10.1093/carcin/7.9.1615 · Cited by 153
An improved apparatus for acute inhalation exposure of rodents to radioactive aerosols
Raabe, O. G., Bennick, J. E., Light, M. E., HOBBS, C. H., Thomas, R. L., & TILLERY, M. I. (1973) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(73)90261-5 · Cited by 150
Postlabeling methods for carcinogen-DNA adduct analysis.
Randerath, K., Randerath, E., Agrawal, H., et al. (1985) · Environmental Health Perspectives · doi:10.1289/ehp.856257 · Cited by 140
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- Harvey, 1980, Carcinogenic hydrocarbons: Metabolic activation and the mechanism of cancer induction, Vol. 2, 439
- Johnson, 1979, The enzymatic preparation of [α-32P]ATP, [α-32P]GTP, [32P]cAMP, [32P]cGMP, and their use in assay of adenylate and guanylate cyclases, and cyclic nucleotide phosphodiesterases, Adv. Cyclic Nucleotide Res., 10, 135
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Particulate matter causes skin barrier dysfunction.
Kim, B. E., Kim, J., Goleva, E., Berdyshev, E., Lee, J., Vang, K. A., Lee, U. H., Han, S., Leung, S., Hall, C. F., et al. (2021) · JCI insight · doi:10.1172/jci.insight.145185 · Cited by 173
“PAHs penetrate into the epidermis easily (8–10) and are stable for 3~6 weeks in vivo (76).”
Background
Metadata
- Authors
- Wolff, R. K., Bond, J. A., Sun, J. D., Henderson, R. F., Harkema, J. R., Griffith, W. C., Mauderly, J. L., & McClellan, R. O.
- Venue
- Toxicology and Applied Pharmacology
- Publisher
- Elsevier BV
- Published
- 1989-02
- Volume
- 97
- Issue
- 2
- Pages
- 289-299
- ISSN
- 0041-008X (ISSN-L)
- OpenAlex
- W2050267695
- Cited by
- 20
- References
- 33
- Citations by year
- 2023: 1 · 2021: 1 · 2019: 1 · 2017: 1 · 2012: 2
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology and Applied Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Energy
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Keywords
- benzo[a]pyrene, carbon black particles, DNA adducts, inhalation exposure, reactive metabolites, lung retention, 32P-postlabeling, rats, air pollution health effects, genotoxicity, reactive oxygen species, oxidative DNA damage
- MeSH terms
- Administration, Inhalation, Adsorption, Age Factors, Animals, Benzo(a)pyrene, Carbon, Carbon Radioisotopes, DNA, Lung, Male, Rats, Inbred F344, Rats
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