Reversion of the attenuated and temperature-sensitive phenotypes of the sabin type 3 strain of poliovirus in vaccinees
Abstract
Isolates of type 3 poliovirus from vaccine-recipients were characterized in terms of virulence, sensitivity of growth to high temperatures, and differences in genome structure from the Sabin type 3 vaccine strain. These included point mutations in the region of the genome coding for the structural proteins and in the 5' noncoding region, and the presence of type 1 or type 2 poliovirus genomic sequences resulting from intertypic recombination. Isolates from healthy vaccinees resembled those from vaccine-associated cases of poliomyelitis in all of these properties. Suppression of the temperature-sensitive phenotype was strictly correlated with reversion to virulence in nonrecombinant type 3 strains. Recombinant isolates were more attenuated than expected, even when they had lost all mutations known to attenuate the type 3 vaccine strain.
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Macadam et al. constructed IRES mutants based upon Sabin 3 that had enhanced genetic stabilities in vitro.
“Finally, Macadam et al. (110) constructed IRES mutants based upon Sabin 3 that had enhanced genetic stabilities in vitro.”
From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [110]
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References 16 · Cited by 125
- Authors
- Macadam, A. J., Arnold, C., Howlett, J., John, A., Marsden, S., Taffs, F., Reeve, P., Hamada, N., Wareham, K., Almond, J., Cammack, N., & Minor, P. D.
- Affiliations
- National Institute for Biological Standards and Control (GB)
- Kurume University (JP)
- University of Reading (GB)
- Corresponding author
- Macadam, A.J.
- ORCID
- Macadam, A.J.
- Venue
- Virology
- Publisher
- Elsevier BV
- Published
- 1989-10
- Volume
- 172
- Issue
- 2
- Pages
- 408-414
- ISSN
- 0042-6822 (ISSN-L)
- OpenAlex
- W2018111000
- Cited by
- 125
- References
- 16
- Citations by year
- 2023: 5 · 2022: 1 · 2020: 2 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 9 · 2013: 5 · 2012: 5
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Virology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- poliovirus type 3, Sabin vaccine strains, vaccine-associated poliomyelitis, temperature-sensitive phenotype, reversion to virulence, intertypic recombination, point mutations, 5' untranslated region, structural protein genes, vaccinees
- MeSH terms
- Base Sequence, Cell Line, Crossing Over, Genetic, Genes, Viral, Humans, Mutation, Phenotype, Poliomyelitis, Poliovirus Vaccine, Oral, RNA, Viral, Temperature, Viral Proteins, Virulence, Poliovirus
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