Inhibition of iron absorption prolongs the life span of Drosophila
Abstract
The life span of Drosophila melanogaster (Oregon R) males was found to be proportional to the logarithm of the iron content of the diet. Life span was also shown to be proportional to the rate of iron accumulation for Drosophila, mice and man. The total body iron content was found to correlate with the total calcium content of adult Drosophila. Iron content during the developmental stages, however, remained relatively constant and did not change with changes in the calcium concentrations. Dietary tea (Camellia sinensis) extracts were found to inhibit the ageing-related accumulation of iron and to prolong the life span of Drosophila by as much as 21.4%. It is concluded that iron accumulation is a significant factor contributing to senescence.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Lowering iron increases the lifespan of Drosophila and yeast.
“lowering iron does increase the lifespan of Drosophila [1215] and yeast [1105].”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [1215]
The citation lists haven’t been fetched yet
References 31 · Cited by 61
- Authors
- Massie, H. R., Aiello, V. R., & Williams, T. R.
- Affiliations
- Masonic Medical Research Laboratory (US)
- Corresponding author
- Massie, Harold R.
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 1993-04
- Volume
- 67
- Issue
- 3
- Pages
- 227-237
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W2022206726
- Cited by
- 61
- References
- 31
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 4 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 5 · 2012: 3
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- iron absorption inhibition, lifespan, aging, iron accumulation, dietary iron, calcium, tea, Camellia sinensis, Drosophila melanogaster, senescence
- MeSH terms
- Absorption, Aging, Animals, Calcium, Diet, Drosophila melanogaster, Iron, Longevity, Male, Tea
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
