Genetic differences in the metabolism of carcinogens and in the binding of benzo[a]pyrene metabolites to DNA
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Cites
Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse
Nebert, D. W., Robinson, J. R., Niwa, A., Kumari, K., & Poland, A. P. (1975) · Journal of Cellular Physiology · doi:10.1002/jcp.1040850407 · Cited by 247 · see citing works
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Rodent Genetic Models of Ah Receptor Signaling
Wilson, R. H., & Bradfield, C. A. (2021) · Drug Metabolism Reviews · doi:10.1080/03602532.2021.1955916 · Cited by 16 · see citing works
“…are useful in examining the consequences of Ahrd versus Ahrb on the same background, therefore eliminating the possibility of non-Ahr genomic elements on endpoints such as susceptibility to BaP carcinogenesis and aryl hydrocarbon hydroxylase activity (Poland et al. 1976; Boobis and Nebert 1977).”
Background
- Authors
- Boobis, A. R., & Nebert, D. W.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Boobis, Alan R.
- Venue
- Advances in Enzyme Regulation
- Publisher
- Elsevier BV
- Published
- 1977-01
- Volume
- 15
- Pages
- 339-362
- ISSN
- 0065-2571 (ISSN-L)
- OpenAlex
- W2044146275
- Cited by
- 12
- References
- 1
- Citations by year
- 2021: 1
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advances in Enzyme Regulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- benzo[a]pyrene, DNA adducts, benzo[a]pyrene metabolites, cytochrome P450, aryl hydrocarbon hydroxylase, Ah locus, genetic polymorphism, strain differences, carcinogenicity, chemical carcinogenesis, reactive intermediates, C3H mice, C57BL/6 mice, DBA/2 mice
- MeSH terms
- Animals, Aryl Hydrocarbon Hydroxylases, Benzopyrenes, Binding Sites, Carcinogens, Chromatography, Gel, Cytochrome P-450 Enzyme System, DNA, Enzyme Induction, Female, Fibrosarcoma, Genes, Liver, Mice, Inbred Strains, Molecular Biology, Neoplasms, Mice, In Vitro Techniques
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