The DOI matches its Crossref record; 276 of the 277 references it cites were found in a registry or an index.
On the role of organized multienzyme systems in cellular metabolism: A general synthesis
Open accessOverview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“The crux of the metabolon is that groups of enzymes and/or proteins within metabolic pathways physically associate.”
From Adrenal Mitochondria and Steroidogenesis: From Individual Proteins to Functional Protein Assemblies (2016) · cites this paper as [26]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Methods of Theoretical Physics
Morse, P. M., Feshbach, H., & Hill, E. L. (1954) · American Journal of Physics · doi:10.1119/1.1933765 · Cited by 13,197
On the nature of allosteric transitions: A plausible model
Monod, J., Wyman, J., & Changeux, J.-P. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80285-6 · Cited by 8,825
Sociobiology: The New Synthesis.
Lenski, G., & Wilson, E. O. (1976) · Social Forces · doi:10.2307/2576242 · Cited by 6,271
Evolutionary Rate at the Molecular Level
KIMURA, M. (1968) · Nature · doi:10.1038/217624a0 · Cited by 3,737
Adaptation and Natural Selection: A Critique of Some Current Evolutionary Thought
Williams, G. C. (2008) · Project Muse (Johns Hopkins University) · doi:10.1515/9781400820108 · Cited by 2,762
Moore, J. W., Pearson, R. G., & Frost, A. A. (1961) · Andalas University Repository (Andalas University) · Cited by 2,342
King, J. L., & Jukes, T. H. (1969) · Science · doi:10.1126/science.164.3881.788 · Cited by 1,768
Nonequilibrium Thermodynamics in Biophysics
Katchalsky, A., & Curran, P. F. (1965) · Harvard University Press eBooks · doi:10.4159/harvard.9780674494121 · Cited by 1,724
Structural chemistry and molecular biology
Rich, A., Davidson, N., & Pauling, L. C. (1968) · Medical Entomology and Zoology · Cited by 1,702
Evolution. The Modern Synthesis.
Huxley, J. S. (1942) · DigitalGeorgetown (Georgetown University Library) · Cited by 1,421
Research works printed but not linked: 66
- Allen, 1976, 73, 665
- Arroyo-Begovich, 1969, 64, 1072
- Atkinson, 1970, Vol. 1, 461
- Ayala, 1974, Amer. Scient., 62, 692
- Berlyn, 1969, J. Bacteriol., 99, 231, 10.1128/jb.99.1.222-230.1969 · DOI
- Bernhardt, 1972, 69, 1868
- Berquist, 1974, 71, 4352
- Boiteux, 1975, 72, 3829
- Brown, 1972, 69, 1467
- Brown, 1976, 73, 143
- Changeux, 1967, 57, 335
- Damjanovich, 1971, Vol. 6, 133
- Deneubourg, 1976, Insectes Sociaux
- Dixon, 1966, Vol. 2, 147
- Doy, 1968, Rev. pure appl. Chem., 18, 41
- Eigen, 1963, Adv. Enzymol., 25, 1
- 1976, 35, 2079
- Florkin, 1974, Vol. 29A, 1
- Fröhlich, 1975, 72, 4211
- Gaertner, 1971, 30, 1131
- Gaertner, 1970, Methods Enzymol., 17, 386
- Ghosh, 1974, Sub-Cell. Biochem., 3, 311
- Gibson, 1968, Bacteriol. Rev., 32, 465, 10.1128/br.32.4_pt_2.465-492.1968 · DOI
- Giles, 1967, 58, 1930
- Giles, 1967, 58, 1453
- Goethe, 1970, Oeuvres d'Histoire Naturelle, Jacob
- Goldbeter, 1973, 70, 3255
- Green, 1957, Harvey Lectures, 52, 177
- Green, 1973, 70, 904
- Huxley, 1869, Eiseley, 335
- Katchalski, 1971, Adv. Enzymol., 34, 445
- Kemeny, 1974, 71, 2655
- Kent, 1975, 72, 1712
- Kirschner, 1972, Vol. 29, 71
- Kozak, 1975, 72, 683
- Laidler, 1951, Archs. Biochem., 30, 226
- Likhtenshtein, 1966, Biofisika, 11, 24
- Lotka, 1922, 8, 147
- Lotka, 1945, Hum. Biol., 17, 167
- Low, 1975, 72, 3305
- L'vov, 1974, Biofizika, 19, 576
- Lynen, 1972, Vol. 29, 177
- Mosbach, 1976, FEBS Lett. (Suppl.), 62, E80
- Odum, 1955, Am. Scient., 43, 331
- Ortoleva, 1975, Vol. 29, 49
- Paley, 1822, Natural Theology, 184
- Prigogine, 1975, Vol. 29, 1
- Rashevsky, 1973, Vol. 3, 177
- Reed, 1970, Vol. 1, 213
- Somogyi, 1971, Acta biochim. biophys. Acad. Sci., Hung., 6, 289
- Somogyi, 1974, Acta biochim. biophys. Acad. Sci., Hung., 9, 175
- Somogyi, 1974, Acta biochim. biophys. Acad. Sci., Hung., 9, 185
- Somogyi, 1971, Acta biochim. biophys. Acad. Sci., Hung., 6, 353
- Somogyi, 1973, Acta biochim. biophys. Acad. Sci., Hung., 8, 153
- Srere, 1973, 70, 2534
- Stoops, 1975, 72, 1940
- Tata, 1971, Sub-Cell Biochem., 1, 83
- Telford, 1975, 72, 3054
- Tewari, 1973, Sub-Cell. Biochem., 2, 287
- Vallee, 1968, 59, 498
- Vegotsky, 1958, Enzymologia, 19, 143
- Wakil, 1966, 55, 880
- Wald, 1963, Vol. 3, 12
- Webb, 1963, Vol. 1
- Welch, 1975, 72, 4218
- Wyman, 1975, 72, 3983
Cited by
MARTINEK, K., LEVASHOV, A. V., KLYACHKO, N., KHMELNITSKI, Y. L., & BEREZIN, I. V. (1986) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1986.tb09512.x · Cited by 504
Dzeja, P., & Terzic, A. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10041729 · Cited by 475
“In this way, adenylate kinase through negative and positive feedback loops governs adenine nucleotide and glycolytic oscillations providing a dynamic component for facilitated intracellular energetic signal communication [5,29,117,119].”
BackgroundEnzyme clustering accelerates processing of intermediates through metabolic channeling
Castellana, M., Wilson, M. Z., Xu, Y., Joshi, P., Cristea, I. M., Rabinowitz, J. D., Gitai, Z., & Wingreen, N. S. (2014) · Nature Biotechnology · doi:10.1038/nbt.3018 · Cited by 445
“(4) This implies a maximal local enzyme density nmax that cannot be exceeded27, which we modeled by the constraint”
Channeling of Substrates and Intermediates in Enzyme-Catalyzed Reactions
Huang, X., Holden, H. M., & Raushel, F. M. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.149 · Cited by 377
On the functional proton current pathway of electron transport phosphorylation
Kell, D. B. (1979) · Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics · doi:10.1016/0304-4173(79)90018-1 · Cited by 339
Metadata
- Authors
- Welch, G. R.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- Corresponding author
- Welch, G.Rickey
- Venue
- Progress in Biophysics and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 1978
- Volume
- 32
- Issue
- 2
- Pages
- 103-191
- ISSN
- 0079-6107 (ISSN-L)
- OpenAlex
- W2133890603
- Cited by
- 260
- References
- 277
- Citations by year
- 2025: 2 · 2024: 2 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2017: 12 · 2016: 4 · 2015: 2 · 2014: 3 · 2012: 3
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 15716 d)
- Locations
- Progress in Biophysics and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- multienzyme systems, enzyme organization, cellular metabolism, enzyme kinetics, metabolic networks
- MeSH terms
- Catalysis, Cells, Diffusion, Escherichia coli, Euglena gracilis, Biological Evolution, Fatty Acids, Kinetics, Mathematics, Mitochondria, Models, Biological, Multienzyme Complexes, Neurospora crassa, Prephenate Dehydratase, Protein Conformation, Pyruvate Dehydrogenase Complex, Saccharomyces cerevisiae, Tetrahydrofolates, Tryptophan Synthase, Fatty Acid Synthases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
