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Cited by 119Viral Infections and Immunology ResearchSystemic Lupus Erythematosus ResearchCardiac Fibrosis and Remodeling

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Heart-specific autoantibodies induced by Coxsackievirus B3: Identification of heart autoantigens

Alvarez, Floria L., Neu, Nikolaus, Rose, Noel R., Craig, Susan W., Beisel, Kirk W.·1987·Clinical Immunology and Immunopathology
DOI 10.1016/0090-1229(87)90164-4
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Abstract

Postinfection sera from A.CA/SnJ A.SW/SnJ, B10.S/SgSf, and B10.PL/SgSf mouse strains which varied in their susceptibility to Coxsackievirus B3-induced immunopathology were suspected to contain autoantibodies against cardiac tissue. These sera were used to identify the target myocardial autoantigen(s). Sera pools were made during the peak of the early, virus-induced myocarditis at 5 and 7 days and during the peak of the late, immunopathic phase of myocarditis at Days 15 and 21 after infection. Only the A.CA/SnJ and A.SW/SnJ strains which develop the immunopathic heart disease had heart-specific autoantibodies as determined by indirect immunofluorescence. This panel of sera pools was then tested against solubilized extracts from whole heart and skeletal muscles. Results from Western immunoblotting analyses demonstrated that antibodies to myosin were a prominent feature in the sera of strains which developed immunopathic myocarditis. The immunopathic sera pools were subsequently assayed against low-salt, high-salt, and a number of detergent extracts of heart and skeletal muscle. Anti-myosin was still the most notable reactivity, even though other autoantigens were detected. Absorption with cardiac myosin removed the vast majority of heart reactivity from the pooled sera derived from the A.CA/SnJ and A.SW/SnJ strains as determined within the limitations of the immunofluorescent and immunochemical assays. Both sarcolemmal and A-band staining patterns were abolished by the cardiac…

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Research works printed but not linked: 14

  1. Lerner, 1975, Mod. Concepts Cardiovasc. Dis., 44, 7
  2. Grist, 1978, Prog. Med. Virol., 24, 114
  3. Maisch, 1982, Clin. Exp. Immunol., 48, 533
  4. Beisel, 1985, Prog. Leuko. Biol., 3, 195
  5. Herskowitz, 1987, J. Amer. Coll. Cardiol.
  6. Huber, 1984, Amer. J. Pathol., 116, 21
  7. Woodruff, 1980, Amer. J. Pathol., 101, 427
  8. Towbin, 1979, 76, 4350
  9. Pollard, 1982, Vol. 85, 331
  10. Parikh, 1977, Vol. 34, 77
  11. de Scheerder, 1985, Clin. Exp. Immunol., 60, 403
  12. Fetisova, 1965, 24, 960
  13. Neu, 1987, J. Immunol.
  14. Ulrich, 1987, Eur. Heart J.

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Metadata

Authors
Alvarez, F. L., Neu, N., Rose, N. R., Craig, S. W., & Beisel, K. W.
Affiliations
Johns Hopkins University (US)
Venue
Clinical Immunology and Immunopathology
Publisher
Elsevier BV
Published
1987-04
Volume
43
Issue
1
Pages
129-139
ISSN
0090-1229 (ISSN-L)
DOI
10.1016/0090-1229(87)90164-4
OpenAlex
W1995259741
Cited by
119
References
21
Citations by year
2026: 3 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 1
FWCI
9.53
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Clinical Immunology and Immunopathology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (HL-33878, HL-30144)
  • National Institute of Allergy and Infectious Diseases (AI13700)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords
coxsackievirus B3, autoimmune myocarditis, cardiac myosin, mouse strain susceptibility, immunopathology, anti-myosin antibodies
MeSH terms
Animals, Antibody Specificity, Autoantibodies, Autoantigens, Coxsackievirus Infections, Mice, Inbred Strains, Myocarditis, Myocardium, Myosins, Enterovirus B, Human, Mice

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