The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Resistance of germfree rats to indomethacin-induced intestinal lesions
Abstract
Indomethacin given orally to conventional rats produced in three days a syndrome, often fatal, of intestinal lesions characterized by multiple ulcers and peritonitis. Male germfree rats were found to be resistant to this effect of indomethacin, while female germfree rats developed very mild lesions. Germfree rats became sensitive again to such lesions when monocontaminated with E. coli. In such animals, however, the lesions were less severe than in conventional animals, presumably because more than one microorganism is necessary for the full syndrome to develop. These results suggest that microorganisms are necessary for the development of indomethacin-induced intestinal lesions. Secondary bile acids, absent in germfree animals, may also be necessary. The prostaglandin deficiency caused by indomethacin appears to weaken the resistance of the intestinal mucosa to microorganisms and/or their toxins. The latter may then penetrate the mucosa, damage the cells and produce ulcers and perforations. Since several prostaglandins also protect against indomethacin-induced lesions, the hypothesis is advanced that certain prostaglandins may protect the mucosa ("cytoprotection") by preventing the spread of microorganisms and/or their toxin through the intestinal wall.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Moreover, germ-free mice are less susceptible to intestinal lesions induced by NSAIDs and it has been documented that NSAID-induced enteropathy is transferable via microbiota[98,101,102].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [102]
Citations
Cites
Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs
VANE, J. R. (1971) · Nature New Biology · doi:10.1038/newbio231232a0 · Cited by 8,605
Small intestinal ulcers and intestinal flora in rats given indomethacin.
Kent, T. H., Cardelli, R. M., & Stamler, F. W. (1969) · PubMed · Cited by 295
An Intestinal Disease Produced Experimentally by a Prostaglandin Deficiency
Robert, A. (1975) · Gastroenterology · doi:10.1016/s0016-5085(19)32433-3 · Cited by 211
Self-citationIndomethacin-induced intestinal lesions in the rat
Brodie, D. A., Cook, P. G., Bauer, B. J., & Dagle, G. E. (1970) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(70)90036-0 · Cited by 197
DETERMINATION OF GERMFREE STATUS*
Wagner, M. (1959) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1959.tb53097.x · Cited by 140
Relationship of the Enterohepatic Cycle to Ulcerogenesis in the Rat Small Bowel with Flufenamic Acid
Wax, J. E., Clinger, W. A., Varner, P., Bass, P., & Winder, C. V. (1970) · Gastroenterology · doi:10.1016/s0016-5085(70)80149-4 · Cited by 105
Fecal neutral steroids and bile acids from germfree rats
Kellogg, T. F., & Wostmann, B. S. (1969) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43040-8 · Cited by 97
Effects of prostaglandins on the stomach and the intestine
Robert, A. (1974) · Prostaglandins · doi:10.1016/s0090-6980(74)80062-6 · Cited by 82
Self-citationBile Acid Metabolism in Gnotobiotic Animals
Kellogg, T. F. (1973) · Springer eBooks · doi:10.1007/978-1-4684-0898-0_11 · Cited by 6
Cited by
Sorted by citations
Items 301–312 of 312
Miscellaneous Diseases of the Small Intestine
Levin, M. S. (2015) · Yamada's Textbook of Gastroenterology · doi:10.1002/9781118512074.ch69
Gastrointestinale Prostaglandine
Peskar, B. M. (1979) · Verhandlungen der Deutschen Gesellschaft für Innere Medizin · doi:10.1007/978-3-642-85454-5_391
Lim, D., Jung, K., Lee, S. B., Park, I. K., Cha, H. J., Park, J. H., Kim, B. G., Jung, S. W., Jeong, I. D., Kim, J. H., et al. (2019) · doi:10.21203/rs.2.16789/v1
Anti-inflammatory analgesics and drugs used in rheumatoid arthritis and gout
Favero, A. D. (1993) · Side effects of drugs annual · doi:10.1016/s0378-6080(05)80193-x
The Microbiome in Critical Illness
Werner, M., & Vigani, A. (2023) · Advances in Small Animal Care · doi:10.1016/j.yasa.2023.04.005
NSAID-Induced Lower Gastrointestinal Bleeding: A Case Report
Nafie, M., Chadbunchachai, W., Lapa, C., Gregory, S., & Nunoo-Mensah, J. W. (2024) · World Journal of Colorectal Surgery · doi:10.4103/wjcs.wjcs_10_24
¿Puede influir la microbiota intestinal en la anemia por pérdidas digestivas?
Santos, M. L., Mateo, S. G., Martí, P. R., & Homedes, C. S. (2026) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2026.502706
Can gut microbiome influence anemia due to gastrointestinal losses?
Santos, M. L., Mateo, S. G., Martí, P. R., & Homedes, C. S. (2026) · Gastroenterología y Hepatología (English Edition) · doi:10.1016/j.gastre.2026.502706
Piccirelli, S., Barberio, B., Tettoni, E., Treppiccione, C., Pezzuto, E., Tabbone, E., Salvi, D., Bertin, L., Gerardi, V., Cesaro, P., et al. (2026) · Pharmaceuticals · doi:10.3390/ph19071045
Johansson, C. (1988) · Springer eBooks · doi:10.1007/978-3-642-73316-1_36
Metadata
- Authors
- Robert, A., & Asano, T.
- Affiliations
- University of Notre Dame (US)
- Venue
- Prostaglandins
- Publisher
- Elsevier BV
- Published
- 1977-08
- Volume
- 14
- Issue
- 2
- Pages
- 333-341
- ISSN
- 0090-6980 (ISSN-L)
- OpenAlex
- W2059605635
- Cited by
- 312
- References
- 9
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 2 · 2021: 9 · 2020: 7 · 2019: 11 · 2018: 2 · 2017: 12 · 2016: 7 · 2015: 11 · 2014: 12 · 2013: 5 · 2012: 11
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Prostaglandins (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- germ-free rats, indomethacin, intestinal lesions, intestinal ulceration, peritonitis, Escherichia coli, secondary bile acids, prostaglandin deficiency, drug-induced intestinal injury, sex differences
- MeSH terms
- Animals, Escherichia coli, Female, Germ-Free Life, Indomethacin, Intestinal Diseases, Intestines, Male, Peritonitis, Prostaglandins E, Rats, Inbred Strains, Sex Factors, Ulcer, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
