Facilitation of self-stimulation behavior following intracerebral microinjections of opioids into the ventral tegmental area
Abstract
The intracerebral microinjection technique was used to localize sites in the brain where morphine facilitated the self-stimulation rate at hypothalamic electrode sites. Bilateral injections of morphine (2 x 1 microgram) into the ventral tegmental area and substantia nigra produced the strongest enhancement at the shortest latencies. At these sites, bilateral injections of 200 ng of morphine also produced a significant enhancement whereas a dose of 50 ng was below threshold for the rate increasing effect. The enhancement by morphine was effectively antagonized by naloxone (5 mg/kg). When injected bilaterally into the same area, D-Ala2-Met5-enkephalinamide (2 x 1 microgram) also induced a strong enhancement of self-stimulation lasting for 70 minutes. A possible dopaminergic substrate for the opiate induced behavioral stimulation is discussed.
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The endogenous opiate system modulates the rewarding and reinforcing effects of food, water, sex, intracranial self-stimulation, and other rewards.
“The endogenous opiate system is well-known to modulate, in part, the rewarding and reinforcing effects of food, water, sex, intracranial self-stimulation, and other rewards (Broekkamp and Phillips 1979; Turkish and Cooper 1983; West et al 1983; Agmo and Berenfeld 1990; Yeomans and Gray 1996; Gerrits et al 2003).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Broekkamp and Phillips 1979
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References 34 · Cited by 122
- Authors
- Broekkamp, C. L., Phillips, A. G., & Cools, A. R.
- Affiliations
- University of British Columbia (CA)
- Radboud University Nijmegen (NL)
- Corresponding author
- Broekkamp, C.L.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1979-09
- Volume
- 11
- Issue
- 3
- Pages
- 289-295
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2062006684
- Cited by
- 122
- References
- 34
- Citations by year
- 2016: 1 · 2012: 1
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- self-stimulation, morphine, ventral tegmental area, substantia nigra, naloxone, D-Ala2-Met5-enkephalinamide, dopamine, intracerebral microinjection, dose-response relationship
- MeSH terms
- Animals, Brain, Enkephalins, Hypothalamus, Injections, Intraventricular, Male, Microinjections, Morphine, Naloxone, Narcotics, Self Stimulation, Time Factors, Rats
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