CoChat
Sign Up
Cited by 421Neurotransmitter Receptor Influence on BehaviorMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.

Conditioned defensive burying: A new paradigm for the study of anxiolytic agents

Open access
Treit, Dallas, Pinel, J.P.J., Fibiger, H.C.·1981·Pharmacology Biochemistry and Behavior
DOI 10.1016/0091-3057(81)90219-7
Open this paper in CoChat — free accountOpen PDF

Abstract

Behavioral paradigms that have been designed to mimic forms of learning that are important for the survival of animals in the wild, rather than to minimize the contributions of adaptive predispositions, may prove to be particularly useful for studying the behavioral effects of drugs. In the present experiments, the propensity of rats to bury sources of aversive stimulation was disrupted in a dose-dependent fashion by a single injection of the anxiolytic drug, diazepam. This suggested that the conditioned defensive burying paradigm could prove to be a valuable addition to the paradigms available for studying anxiolytic effects. Supporting this view were two additional observations. First, the relative potencies of diazepam, chlordiazepoxide, and pentobarbital in the burying paradigm compared favorably with their relative potencies in clinical settings. Second, the effects of anxiolytics on conditioned burying appeared to be dissociable from the effects of other drugs that disrupt this behavior.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/0091-3057(81)90219-7

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 46 references

Research works printed but not linked: 7

  1. Delay, 1952, Trente-huit cas de psychoses traifees par la cure prolongee et continue de 4560 R.P., C.r. Congr. Med. Alien. Neurol. Lang fr., 50, 497
  2. Holtzman, 1973, Operant behaviorin the morphine-dependent rhesus monkey, J. Pharmac. exp. Ther, 184, 528
  3. Jenner, 1967, Comparison of diazepam, chlordiazepoxide and amylobarbitone, Dis. nerv. Syst., 28, 245
  4. Mandler, 1962, Emotion, Vol. 1
  5. Pinel, J. P. J. and D. Treit. The conditioned defensive burying paradigm and behavioral neuroscience. In: Behavioral Contributions to Brain Research, edited by T. Robinson. New York: Oxford University Press, in press.
  6. Ray, 1965, Tranquilizer effects as a function of experimental anxiety procedures, Archs int. Pharmacodyn. Thér., 153, 49
  7. Sansone, 1975, Benzodiazepines and amphetamine on avoidance behavior in mice, Arch int. Pharmacodyn. Thér., 218, 125

Cited by

Sorted by citations

Items 401–421 of 421

Related

See all

Metadata

Authors
Treit, D., Pinel, J. P. J., & Fibiger, H. C.
Affiliations
University of British Columbia (CA)
Corresponding author
Pinel, J.P.J.
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
1981-10
Volume
15
Issue
4
Pages
619-626
ISSN
0091-3057 (ISSN-L)
DOI
10.1016/0091-3057(81)90219-7
OpenAlex
W2022356586
Cited by
420
References
46
Citations by year
2025: 3 · 2024: 6 · 2023: 4 · 2022: 11 · 2021: 4 · 2020: 8 · 2019: 5 · 2018: 12 · 2017: 6 · 2016: 6 · 2015: 16 · 2014: 9 · 2013: 17 · 2012: 16
FWCI
5.08
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • cIRcle (University of British Columbia) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
anxiolytics, diazepam, chlordiazepoxide, pentobarbital, aversive stimulation, drug potency, behavioral paradigms, rats
MeSH terms
Animals, Chlordiazepoxide, Conditioning, Operant, Diazepam, Dose-Response Relationship, Drug, Electroshock, Habituation, Psychophysiologic, Male, Pentobarbital, Psychotropic Drugs, Anti-Anxiety Agents, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review