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Cited by 21Neuropeptides and Animal PhysiologyPain Mechanisms and TreatmentsPain Management and Opioid Use

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Naloxone-induced analgesia: Involvement of κ-opiate receptors

Bianchi, Mauro, Panerai, Alberto E.·1993·Pharmacology Biochemistry and Behavior
DOI 10.1016/0091-3057(93)90331-m
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Abstract

Rats treated with an acute high dose (30 mg/kg) or 4 days with a lower dose (5 mg/kg) of naloxone or naltrexone show an analgesic response at the hot-plate test. This paradoxical analgesic effect of the two mu-opiate receptor antagonists is blocked by the kappa opiate receptor antagonist MR 1452, and is modulated by the kappa opiate receptor agonist U 50-488. Our results suggest that kappa opiate receptors are involved in naloxone-induced analgesia and are consistent with a high degree of plasticity of the opiatergic system.

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Citations

Cites

Research works printed but not linked: 23

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Metadata

Authors
Bianchi, M., & Panerai, A. E.
Affiliations
University of Milan (IT)
Corresponding author
Panerai, Alberto E.
ORCID
Panerai, Alberto E.
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
1993-09
Volume
46
Issue
1
Pages
145-148
ISSN
0091-3057 (ISSN-L)
DOI
10.1016/0091-3057(93)90331-m
OpenAlex
W2095029167
Cited by
21
References
1
Citations by year
2025: 1 · 2024: 3 · 2021: 1 · 2013: 1
FWCI
0.36
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Keywords
naloxone, naltrexone, kappa opioid receptor, U50,488, hot plate test, opioid analgesia
MeSH terms
Analgesia, Analgesics, Animals, Benzomorphans, Male, Naloxone, Naltrexone, Narcotic Antagonists, Pyrrolidines, Rats, Sprague-Dawley, Pain Threshold, Receptors, Opioid, mu, Receptors, Opioid, kappa, 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer, Rats

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