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Cited by 63Neurotransmitter Receptor Influence on BehaviorMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

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Effect of fluoxetine on learning and memory involves multiple 5-HT systems

Meneses, Alfredo, Hong, Enrique·1995·Pharmacology Biochemistry and Behavior
DOI 10.1016/0091-3057(95)00102-3
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Abstract

Diverse evidence suggests that 5-HT uptake blockers enhance learning and memory. However, there is no information about the mechanisms of action involved in such effects. The aim of the present work was to investigate the nature of the receptors involved in the effects of fluoxetine on learning. Therefore, a dose-response curve of posttraining injection (intraperitoneal) of fluoxetine was carried out in an associative learning task (auto-shaping). Fluoxetine or the vehicle was injected 10 min after 5-HT antagonists: (+/-)-pindolol, (+/-)-propanolol, NAN-190, ketanserin, ritanserin, mesulergine, MDL 72222, or SDZ 205-557. Presynaptic activity was eliminated by means of chloroamphetamine pretreatment. Scopolamine (an anticholinergic) and dizocilpine (a noncompetitive NMDA receptor antagonist) were also used. Results showed that fluoxetine enhanced learning of the conditioned response (CR) in a dose-dependent fashion. All 5-HT antagonists had no effects by themselves but inhibited the effects of fluoxetine at different degrees. Decrement of CR produced by scopolamine was reversed by fluoxetine. Dizocilpine did not affect CR but prevented the effects of fluoxetine. The present findings suggest that the actions of fluoxetine on learning are due to an interaction with multiple receptors of postsynaptic nature.

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Metadata

Authors
Meneses, A., & Hong, E.
Affiliations
Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (MX)
Corresponding author
Meneses, Alfredo
ORCID
Hong, Enrique
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
1995-10
Volume
52
Issue
2
Pages
341-346
ISSN
0091-3057 (ISSN-L)
DOI
10.1016/0091-3057(95)00102-3
OpenAlex
W2052878380
Cited by
63
References
1
Citations by year
2026: 1 · 2022: 1 · 2021: 2 · 2018: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 1
FWCI
2.26
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
Eli Lilly and Company
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
fluoxetine, learning, memory, serotonin, serotonin receptors, 5-HT receptor antagonists, conditioned response, scopolamine, MK-801, NMDA receptor, postsynaptic receptors
MeSH terms
Animals, Conditioning, Operant, Dextroamphetamine, Dose-Response Relationship, Drug, Fluoxetine, Injections, Intraperitoneal, Learning, Male, Memory, Synaptic Transmission, Parasympatholytics, Scopolamine, Serotonin, Sympathomimetics, Dizocilpine Maleate, Rats, Wistar, Selective Serotonin Reuptake Inhibitors, Cholinergic Antagonists, Excitatory Amino Acid Antagonists, Rats

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