Nucleotide sequence of the AIDS virus, LAV
Abstract
The complete 9193-nucleotide sequence of the probable causative agent of AIDS, lymphadenopathy-associated virus (LAV), has been determined. The deduced genetic structure is unique: it shows, in addition to the retroviral gag, pol, and env genes, two novel open reading frames we call Q and F. Remarkably, Q is located between pol and env and F is half-encoded by the U3 element of the LTR. These data place LAV apart from the previously characterized family of human T cell leukemia/lymphoma viruses.
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HIV-1 uses human tRNA Lys isoacceptor 3 (tRNA Lys,3) as its reverse transcription primer.
“For HIV-1, the identity of the primer is the human tRNA Lys isoacceptor 3 (tRNA Lys,3 ) (9).”
From Role of host tRNAs and aminoacyl-tRNA synthetases in retroviral replication (2019) · cites this paper as [9]
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Characterization of ribosomal frameshifting in HIV-1 gag-pol expression
Jacks, T., Power, M. D., Masiarz, F. R., Luciw, P. A., Barr, P. J., & Varmus, H. E. (1988) · Nature · doi:10.1038/331280a0 · Cited by 966 · see citing works
Dyda, F., Hickman, A. B., Jenkins, T. M., Engelman, A., Craigie, R., & Davies, D. R. (1994) · Science · doi:10.1126/science.7801124 · Cited by 810 · see citing works
Laughrea, M., & Jette, L. (1994) · Biochemistry · doi:10.1021/bi00249a035 · Cited by 237 · see citing works
Biochemical and immunological analysis of human immunodeficiency virus gag gene products p17 and p24
Veronese, F. D., Copeland, T. D., Oroszlan, S., Gallo, R. C., & Sarngadharan, M. G. (1988) · Journal of Virology · doi:10.1128/jvi.62.3.795-801.1988 · Cited by 203 · see citing works
Park, J., & Morrow, C. D. (1991) · Journal of Virology · doi:10.1128/jvi.65.9.5111-5117.1991 · Cited by 163 · see citing works
Avoiding drug resistance in HIV reverse transcriptase
Cilento, M. E., Kirby, K. A., & Sarafianos, S. G. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00967 · Cited by 106 · see citing works
Role of host tRNAs and aminoacyl-tRNA synthetases in retroviral replication
Jin, D., & Musier-Forsyth, K. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev118.002957 · Cited by 67 · see citing works
“For HIV-1, the identity of the primer is the human tRNA isoacceptor 3 (tRNA) (9).”
Background
- Authors
- Wain-Hobson, S., Sonigo, P., Danos, O., Cole, S., & Alizon, M.
- Affiliations
- Institut Pasteur (FR)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1985-01
- Volume
- 40
- Issue
- 1
- Pages
- 9-17
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2117149353
- Cited by
- 1,202
- References
- 0
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 9 · 2019: 10 · 2018: 10 · 2017: 5 · 2016: 4 · 2015: 7 · 2014: 6 · 2013: 12 · 2012: 9
- FWCI
- 25.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Keywords
- lymphadenopathy-associated virus, HIV-1, AIDS virus, nucleotide sequence, gag gene, pol gene, env gene, long terminal repeat
- MeSH terms
- Acquired Immunodeficiency Syndrome, Amino Acid Sequence, Antigens, Viral, Base Sequence, Cloning, Molecular, DNA, Viral, Genes, Genes, Viral, Humans, Species Specificity, Viral Envelope Proteins, Viral Proteins, Gene Products, gag, Deltaretrovirus
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