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A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene
Open accessAbstract
Krüppel (Kr), a segmentation gene of Drosophila, encodes a protein sharing structural features of the DNA-binding "finger motif" of TFIIIA, a Xenopus transcription factor. Low-stringency hybridization of the Kr finger coding sequence revealed multiple copies of homologous DNA sequences in the genomes of Drosophila and other eukaryotes. Molecular analysis of one Kr-homologous DNA clone identified a developmentally regulated gene. Its product, a finger protein, relates to Kr by the invariant positioning of crucial amino acid residues within the finger repeats and by a stretch of seven amino acids connecting the finger loops, the "H/C link." This H/C link is conserved in several nuclear and chromosome-associated proteins of Drosophila and other eukaryotic organisms including mammals. Our results demonstrate a new subfamily of evolutionarily conserved nuclear and possibly DNA-binding proteins that again relate to a Drosophila segmentation gene as in the case of the homeo domain.
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Cited by
Zinc Finger-DNA Recognition: Crystal Structure of a Zif268-DNA Complex at 2.1 Å
Pavletich, N. P., & Pabo, C. O. (1991) · Science · doi:10.1126/science.2028256 · Cited by 2,061
Call, K. M., Glaser, T., Ito, C. Y., Buckler, A. J., Pelletier, J., Haber, D. A., Rose, E. A., Kral, A., Yeger, H., Lewis, W. H., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90601-a · Cited by 1,876
Kadonaga, J. T., Carner, K. R., Masiarz, F. R., & Tjian, R. (1987) · Cell · doi:10.1016/0092-8674(87)90594-0 · Cited by 1,616
Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping
Gessler, M., Poustka, A., Cavenee, W., Neve, R. L., Orkin, S. H., & Bruns, G. A. P. (1990) · Nature · doi:10.1038/343774a0 · Cited by 1,292
Sukhatme, V. P., Cao, X., Chang, L. C., Tsai-Morris, C.-H., Stamenkovich, D., Ferreira, P. C. P., Cohen, D. R., Edwards, S. A., Shows, T. B., Curran, T., et al. (1988) · Cell · doi:10.1016/0092-8674(88)90485-0 · Cited by 1,250
Metadata
- Authors
- Schuh, R., Aicher, W., Gaul, U., Côte, S., Preiss, A., Maier, D., Seifert, E., Nauber, U., Schröder, C., Kemler, R., & Jäckle, H.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1986-12
- Volume
- 47
- Issue
- 6
- Pages
- 1025-1032
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2111224981
- Cited by
- 410
- References
- 0
- FWCI
- 7.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Schuh, R., Aicher, W., Gaul, U., Côte, S., Preiss, A., Maier, D., Seifert, E., Nauber, U., Schröder, C., Kemler, R., & Jäckle, H. (1986). A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene. Cell. https://doi.org/10.1016/0092-8674(86)90817-2
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