The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Pathogenesis of Burkitt lymphoma: Expression of an activated c-myc oncogene causes the tumorigenic conversion of EBV-infected human B lymphoblasts
Open accessAbstract
To study the pathogenesis of Burkitt lymphoma, we introduced activated c-myc genes into human EBV-infected lymphoblastoid cells derived from in vitro infection of normal cord blood or directly from infected peripheral blood from AIDS patients. In both cell types the constitutive expression of exogenous c-myc caused negative regulation of endogenous c-myc expression, changes in growth properties typical of transformed cells, and acquisition of tumorigenicity in immunodeficient mice. In all myc-transfected populations the degree of malignancy directly correlated with the level of c-myc mRNA. EBV infection and c-myc activation are thus sufficient for the tumorigenic conversion of human B cells in vitro, strongly supporting the hypothesis that these same two pathogenetic steps may be involved in the in vivo development of Burkitt lymphoma.
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Cited by
Gao, P., Tchernyshyov, I., Chang, T.-C., Lee, Y.-S., Kita, K., Ochi, T., Zeller, K. I., De Marzo, A. M., Van Eyk, J. E., Mendell, J. T., et al. (2009) · Nature · doi:10.1038/nature07823 · Cited by 2,124
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c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth
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Metadata
- Authors
- Lombardi, L., Newcomb, E. W., & Dalla-Favera, R.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1987-04
- Volume
- 49
- Issue
- 2
- Pages
- 161-170
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2153393494
- Cited by
- 295
- References
- 44
- FWCI
- 13.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Pathogenesis of Burkitt lymphoma: Expression of an activated c-myc oncogene causes the tumorigenic conversion of EBV-infected human B lymphoblasts. https://app.cochat.ai/papers/10.1016/0092-8674(87)90556-3
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- Lombardi, L., Newcomb, E. W., & Dalla-Favera, R. (1987). Pathogenesis of Burkitt lymphoma: Expression of an activated c-myc oncogene causes the tumorigenic conversion of EBV-infected human B lymphoblasts. Cell. https://doi.org/10.1016/0092-8674(87)90556-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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