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Involvement of GTP-binding “G” proteins in transport through the Golgi stack
Open accessAbstract
GTP gamma S irreversibly inhibits protein transport between successive compartments of the Golgi stack in a cell-free system. Fluoride, potentiated by the addition of aluminum ion, also causes a strong inhibition. These are hallmarks of the involvement of a guanine nucleotide-binding or regulatory "G" protein. Inhibition by GTP gamma S requires a cytosolic inhibitory factor that binds to Golgi membranes during inhibition. Preincubation experiments reveal that GTP gamma S blocks the function of acceptor Golgi but not donor Golgi membranes. More specifically, a processing step in between vesicle attachment and the actual fusion event seems to be affected. Electron microscopy demonstrates a corresponding 5-fold accumulation of non-clathrin-coated buds and vesicles associated with the Golgi cisternae during inhibition by GTP gamma S.
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Citations
Cited by
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Goldstein, J. L., & Brown, M. S. (1990) · Nature · doi:10.1038/343425a0 · Cited by 5,394
Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments
Chavrier, P., Parton, R. G., Hauri, H. P., Simons, K., & Zerial, M. (1990) · Cell · doi:10.1016/0092-8674(90)90369-p · Cited by 1,166
Viral and Cellular Membrane Fusion Proteins
White, J. M. (1990) · Annual Review of Physiology · doi:10.1146/annurev.ph.52.030190.003331 · Cited by 522
ADP-Ribosylation Factor 6 Regulates a Novel Plasma Membrane Recycling Pathway
Radhakrishna, H., & Donaldson, J. G. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.1.49 · Cited by 508
Tisdale, E. J., Bourne, J. R., Khosravi-Far, R., Der, C. J., & Balch, W. E. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.4.749 · Cited by 500
Metadata
- Authors
- Melançon, P., Glick, B. S., Malhotra, V., Weidman, P. J., Serafini, T., Gleason, M. L., Orci, L., & Rothman, J. E.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1987-12
- Volume
- 51
- Issue
- 6
- Pages
- 1053-1062
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1985700603
- Cited by
- 501
- References
- 0
- FWCI
- 18.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Melançon, P., Glick, B. S., Malhotra, V., Weidman, P. J., Serafini, T., Gleason, M. L., Orci, L., & Rothman, J. E. (1987). Involvement of GTP-binding “G” proteins in transport through the Golgi stack. Cell. https://doi.org/10.1016/0092-8674(87)90591-5
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