The DOI matches its Crossref record; 32 of the 34 references it cites were found in a registry or an index.
Retroviral DNA integration: Structure of an integration intermediate
Abstract
The structure of a presumptive DNA intermediate in the integration of retroviral DNA was studied in a cell-free reaction with exogenously added target DNA. The product made by viral core particles of Moloney murine leukemia virus (Mo-MLV) containing linear viral DNA has a structure consistent with an integration mechanism similar to that observed during bacteriophage Mu transposition. In this intermediate, the 3' ends of the LTR sequences are joined to the target DNA, while the 5' ends of the viral DNA remain unjoined. The 5' ends of the LTR sequences in the intermediate are exactly the same as those found in the unintegrated linear double-stranded viral DNA. This result demonstrates that the linear form of Mo-MLV DNA can integrate directly without prior circularization.
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In the citing paper
“During this 3′ end processing, IN removes the few nucleotides (di- or trinucleotides, depending upon the retrovirus) by hydrolyzing the phosphodiester bond at both the U3 and U5 att sites downstream of the phylogenetically conserved CA dinucleotide, generating staggered ends (Fujiwara and Mizuuchi 1988, Brown et al. 1989, Roth et al. 1989).”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Fujiwara and Mizuuchi 1988
In the citing paper
“These studies demonstrated that PIC-containing reverse-transcribed dsDNA could be integrated into a heterologous DNA (Fujiwara and Mizuuchi 1988, Fujiwara and Craigie 1989, Bushman et al. 1990, Craigie et al. 1990, Katz et al. 1990, Lee and Coffin 1990, Engelman et al. 1991, Brown 1997).”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Fujiwara and Mizuuchi 1988
In the citing paper
“Secondly, the intasome containing the processed viral DNA attaches to the host cell DNA, which facilitates the cleavage of the host cell DNA in a staggered fashion by IN using viral DNA 3′-hydroxyls as nucleophiles (Fujiwara and Mizuuchi 1988, Bushman and Craigie 1991, Engelman et al. 1991).”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Fujiwara and Mizuuchi 1988
Citations
Cites
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
Feinberg, A. P., & Vogelstein, B. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90418-9 · Cited by 24,512
Church, G. M., & Gilbert, W. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.7.1991 · Cited by 8,213
A new method for sequencing DNA.
Maxam, A. M., & Gilbert, W. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.2.560 · Cited by 7,929
Rapid transfer of DNA from agarose gels to nylon membranes
Reed, K. C., & Mann, D. A. (1985) · Nucleic Acids Research · doi:10.1093/nar/13.20.7207 · Cited by 1,731
CELLULAR ONCOGENES AND RETROVIRUSES
Bishop, J. M. (1983) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.52.070183.001505 · Cited by 1,666
Mueller, R. F. (1984) · Journal of Medical Genetics · doi:10.1136/jmg.21.1.79 · Cited by 583
Shapiro, J. A. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.4.1933 · Cited by 511
Correct integration of retroviral DNA in vitro
Brown, P. O., Bowerman, B. A., VARMUS, H. E., & Bishop, J. M. (1987) · Cell · doi:10.1016/0092-8674(87)90287-x · Cited by 460
(1989) · Research in Microbiology · doi:10.1016/0923-2508(89)90071-5 · Cited by 372
Ty element transposition: Reverse transcriptase and virus-like particles
Garfinkel, D. J., Boeke, J. D., & Fink, G. R. (1985) · Cell · doi:10.1016/0092-8674(85)90108-4 · Cited by 352
Cited by
Sorted by citations
Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system
Agrawal, A., Eastman, Q. M., & Schatz, D. G. (1998) · Nature · doi:10.1038/29457 · Cited by 811
Molecular Targets for AIDS Therapy
Mitsuya, H., Yarchoan, R., & Broder, S. E. (1990) · Science · doi:10.1126/science.1699273 · Cited by 731
HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer
Engelman, A., Mizuuchi, K., & Craigie, R. (1991) · Cell · doi:10.1016/0092-8674(91)90297-c · Cited by 655
Self-citationMiller, M. D., Farnet, C. M., & Bushman, F. D. (1997) · Journal of Virology · doi:10.1128/jvi.71.7.5382-5390.1997 · Cited by 620
Bushman, F. D., & Craigie, R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.4.1339 · Cited by 410
Metadata
- Authors
- Fujiwara, T., & Mizuuchi, K.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Mizuuchi, Kiyoshi
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1988-08
- Volume
- 54
- Issue
- 4
- Pages
- 497-504
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1992073293
- Cited by
- 385
- References
- 34
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 7 · 2014: 5 · 2013: 5 · 2012: 10
- FWCI
- 14.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- retroviral integration, Moloney murine leukemia virus, long terminal repeat, target DNA
- MeSH terms
- Cell-Free System, DNA, Recombinant, DNA, Viral, Moloney murine leukemia virus, Retroviridae
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