Cited by 160T-cell and Retrovirus StudiesHIV Research and TreatmentCellular transport and secretion

The DOI matches its Crossref record; 62 of the 67 references it cites were found in a registry or an index.

A single amino acid substitution within the matrix protein of a type D retrovirus converts its morphogenesis to that of a type C retrovirus

Rhee, Sung S., Hunter, Eric·1990·Cell

Open this paper in CoChat — free account

Abstract

Two different morphogenic processes of retroviral capsid assembly have been observed: the capsid is either assembled at the plasma membrane during the budding process (type C), or preassembled within the cytoplasm (types B and D). We describe here a gag mutant of Mason-Pfizer monkey virus, a type D retrovirus, in which a tryptophan substituted for an arginine in the matrix protein results in efficient assembly of capsids at the plasma membrane through a morphogenic process similar to that of type C retroviruses. We conclude that a type D retrovirus Gag polyprotein contains an additional, dominant signal that prevents immediate transport of precursors from the site of biosynthesis to the plasma membrane. Instead, they are directed to and retained at a cytoplasmic site where a concentration sufficient for self-assembly into capsids occurs. Thus, capsid assembly processes for different retroviruses appear to differ only in the intracellular site to which capsid precursors are directed.

Integrity signals

Registry

Crossref · 10.1016/0092-8674(90)90289-q

Cites

62 of 62 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572
A new technique for the assay of infectivity of human adenovirus 5 DNA
Graham, F. L., & van der Eb, A. J. (1973) · Virology · doi:10.1016/0042-6822(73)90341-3 · Cited by 9,302
High-Efficiency Transformation of Mammalian Cells by Plasmid DNA
Chen, C., & Okayama, H. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.8.2745 · Cited by 5,327
Intracellular Aspects of the Process of Protein Synthesis
Palade, G. E. (1975) · Science · doi:10.1126/science.1096303 · Cited by 3,583
Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.
Blobel, G., & Dobberstein, B. (1975) · The Journal of Cell Biology · doi:10.1083/jcb.67.3.835 · Cited by 3,014
A short amino acid sequence able to specify nuclear location
Kalderon, D., Roberts, B., Richardson, W. D., & Smith, A. E. (1984) · Cell · doi:10.1016/0092-8674(84)90457-4 · Cited by 2,511
Intracellular protein topogenesis
Blobel, G. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1496 · Cited by 1,393
Sequence requirements for nuclear location of simian virus 40 large-T antigen
Kalderon, D., Richardson, W. D., Markham, A. F., & Smith, A. E. (1984) · Nature · doi:10.1038/311033a0 · Cited by 1,286
Homologous plant and bacterial proteins chaperone oligomeric protein assembly
Hemmingsen, S. M., Woolford, C. A., van der Vies, S. M., Tilly, K., Dennis, D. T., Georgopoulos, C. P., Hendrix, R. W., & Ellis, R. J. (1988) · Nature · doi:10.1038/333330a0 · Cited by 1,283
Three-Dimensional Structure of Poliovirus at 2.9 Å Resolution
Hogle, J. M., Chow, M., & Filman, D. J. (1985) · Science · doi:10.1126/science.2994218 · Cited by 1,267

Show all 67 references

Research works printed but not linked: 1

Marx, 1988, Methods in laboratory investigation: computer emulation of thin section electron microscopy predicts an envelope-associated icosadeltahedral capsid for human immunodeficiency virus, Lab. Invest. Meth. Cell Biol., 58, 112

Sorted by citations

Items 101–160 of 160

Importance of p12 protein in Mason-Pfizer monkey virus assembly and infectivity
Sommerfelt, M. A., Rhee, S. S., & Hunter, E. (1992) · Journal of Virology · doi:10.1128/jvi.66.12.7005-7011.1992 · Cited by 28
Self-citation
Intracellular Distribution of Human T-Cell Leukemia Virus Type 1 Gag Proteins Is Independent of Interaction with Intracellular Membranes
Blanc, I., Blot, V., Bouchaert, I., Salamero, J., Goud, B., Rosenberg, A. R., & Dokhélar, M. (2002) · Journal of Virology · doi:10.1128/jvi.76.2.905-911.2002 · Cited by 26
Three-dimensional Structure of a Monomeric Form of a Retroviral Protease
Veverka, V., Bauerová, H., Zábranský, A., Lang, J., Ruml, T., Pichová, I., & Hrabal, R. (2003) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.08.049 · Cited by 26
A Cell-Line-Specific Defect in the Intracellular Transport and Release of Assembled Retroviral Capsids
Parker, S. D., & Hunter, E. (2000) · Journal of Virology · doi:10.1128/jvi.74.2.784-795.2000 · Cited by 24
Self-citation
Nuclear Localization of the Functional Bel 1 Transactivator but Not of the Gag Proteins of the Feline Foamy Virus
Bodem, J., Zemba, M., & Flügel, R. M. (1998) · Virology · doi:10.1006/viro.1998.9369 · Cited by 22
Use of heterologous expression systems to study retroviral morphogenesis.
Boulanger, P., & Jones, I. (1996) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-642-80145-7_8 · Cited by 24
Direct evidence for intracellular anterograde co-transport of M-PMV Gag and Env on microtubules
Pereira, L. E., Clark, J., Grznárová, P., Wen, X., LaCasse, R. A., Ruml, T., Spearman, P. W., & Hunter, E. (2013) · Virology · doi:10.1016/j.virol.2013.11.006 · Cited by 20
Self-citation
Sequences in the 5′ Leader of Mason-Pfizer Monkey Virus Which Affect Viral Particle Production and Genomic RNA Packaging: Development of MPMV Packaging Cell Lines
Guesdon, F., Greatorex, J. S., Rhee, S. R., Fisher, R., Hunter, E., & Lever, A. M. L. (2001) · Virology · doi:10.1006/viro.2001.1061 · Cited by 19
Self-citation
The RNA Binding G-patch Domain in Retroviral Protease Is Important for Infectivity and D-type Morphogenesis of Mason-Pfizer Monkey Virus
Zábranská, H., Štokrová, J., Střı́šovský, K., Hunter, E., Ruml, T., & Pichová, I. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508031200 · Cited by 19
Self-citation
Structural analysis of pleomorphic and asymmetric viruses using cryo-electron tomography and subtomogram averaging
Obr, M., & Schur, F. K. M. (2019) · Advances in virus research · doi:10.1016/bs.aivir.2019.07.008 · Cited by 19
Purification of immature cores of mouse mammary tumor virus and immunolocalization of protein domains
Menéndez-Arias, L., Risco, C., Pinto da Silva, P., & Oroszlan, S. (1992) · Journal of Virology · doi:10.1128/jvi.66.9.5615-5620.1992 · Cited by 18
Conditions for Copackaging Rous Sarcoma Virus and Murine Leukemia Virus Gag Proteins during Retroviral Budding
Bennett, R., & Wills, J. (1999) · Journal of Virology · doi:10.1128/jvi.73.3.2045-2051.1999 · Cited by 20
The pp24 phosphoprotein of Mason-Pfizer monkey virus contributes to viral genome packaging
Bohl, C. R., Brown, S. M., & Weldon, R. A. (2005) · Retrovirology · doi:10.1186/1742-4690-2-68 · Cited by 17
An Early Stage of Mason-Pfizer Monkey Virus Budding Is Regulated by the Hydrophobicity of the Gag Matrix Domain Core
Stansell, E., Tytler, E. M., Walter, M. R., & Hunter, E. (2004) · Journal of Virology · doi:10.1128/jvi.78.10.5023-5031.2004 · Cited by 14
Self-citation
Role of matrix protein in the type D retrovirus replication cycle: importance of the arginine residue at position 55.
Yasuda, J., & Hunter, E. (2000) · Virology · doi:10.1006/viro.1999.0179 · Cited by 13
Self-citation
Evolution of feline immunodeficiency virus Gag proteins
Burkala, E. J., & Poss, M. L. (2007) · Virus Genes · doi:10.1007/s11262-006-0058-8 · Cited by 13
Inhibition of viral assembly in murine cells by HIV-1 matrix.
Hübner, W., & Chen, B. K. (2006) · Virology · doi:10.1016/j.virol.2006.04.024 · Cited by 18
Mutations in the Basic Region of the Mason-Pfizer Monkey Virus Nucleocapsid Protein Affect Reverse Transcription, Genomic RNA Packaging, and the Virus Assembly Site
Dostálková, A., Kaufman, F., Křížová, I., Kultová, A., Strohalmová, K., Hadravová, R., Ruml, T., & Rumlová, M. (2018) · Journal of Virology · doi:10.1128/jvi.00106-18 · Cited by 11
Identification of Pr78Gag Binding Sites on the Mason-Pfizer monkey virus genomic RNA packaging determinants
Pitchai, F. N. N., Chameettachal, A., Vivet-Boudou, V., Ali, L. M., Pillai, V. N., Krishnan, A., Bernacchi, S., Mustafa, F., Marquet, R., & Rizvi, T. A. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.166923 · Cited by 12
Expression, purification, and characterization of biologically active full-length Mason-Pfizer monkey virus (MPMV) Pr78Gag
Pitchai, F. N. N., Ali, L. M., Pillai, V. N., Chameettachal, A., Ashraf, S. M., Mustafa, F., Marquet, R., & Rizvi, T. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-30142-0 · Cited by 13
Pericentriolar targeting of the mouse mammary tumor virus GAG protein
Zhang, G., Sharon, D., Jovel, J., Liu, L., Wine, E., Tahbaz, N., Indik, S., & Mason, A. (2015) · PLOS ONE · doi:10.1371/journal.pone.0131515 · Cited by 12
Nonmyristoylated Matrix Protein from the Mason–Pfizer Monkey Virus Forms Oligomers
Vlach, J., Srb, P., Prchal, J., Grocký, M., Lang, J., Ruml, T., & Hrabal, R. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.05.063 · Cited by 12
Virus-Host Cell Interactions
Ball, L. A. (2010) · Wiley eBooks · doi:10.1002/9780470688618.taw0218 · Cited by 11
Amino Acid Residues in the Cytoplasmic Domain of the Mason-Pfizer Monkey Virus Glycoprotein Critical for Its Incorporation into Virions
Song, C., Micoli, K., Bauerová, H., Pichová, I., & Hunter, E. (2005) · Journal of Virology · doi:10.1128/jvi.79.18.11559-11568.2005 · Cited by 10
Self-citation
Specificity of Plasma Membrane Targeting by the Rous Sarcoma Virus Gag Protein
Scheifele, L. Z., Rhoads, J. D., & Parent, L. J. (2002) · Journal of Virology · doi:10.1128/jvi.77.1.470-480.2003 · Cited by 10
Localization of self-interacting domains within betaretrovirus Gag polyproteins
Zábranský, A., Sakalian, M., & Pichová, I. (2005) · Virology · doi:10.1016/j.virol.2004.12.007 · Cited by 10
Retroelement particles as purification, presentation and targeting vehicles
Kingsman, A. J. (1991) · Trends in biotechnology · doi:10.1016/0167-7799(91)90100-v · Cited by 10
A Mason-Pfizer Monkey Virus Gag-GFP Fusion Vector Allows Visualization of Capsid Transport in Live Cells and Demonstrates a Role for Microtubules
Clark, J., Grznárová, P., Stansell, E., Diehl, W. E., Lipov, J., Spearman, P. W., Ruml, T., & Hunter, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083863 · Cited by 9
Self-citation
Multimerization of the p12 domain is necessary for Mason–Pfizer monkey virus Gag assembly in vitro
Knejzlı́k, Z., Smékalová, Z., Ruml, T., & Sakalian, M. (2007) · Virology · doi:10.1016/j.virol.2007.03.053 · Cited by 9
Bacterial expression, purification, andin vitro N-myristoylation of HIV-1 pl7gag
Burnette, B., Kahn, R., Glover, C. J., & Felsted, R. L. (1992) · Protein Expression and Purification · doi:10.1016/s1046-5928(05)80041-5 · Cited by 9
A myristoyl switch at the plasma membrane triggers cleavage and oligomerization of Mason-Pfizer monkey virus matrix protein
Častorálová, M., Sýs, J., Prchal, J., Pavlů, A., Prokopová, L., Briki, Z., Hubálek, M., & Ruml, T. (2024) · eLife · doi:10.7554/elife.93489 · Cited by 7
Roles of the three L‐domains in β‐retrovirus budding
Narahara, C., & Yasuda, J. (2015) · Microbiology and Immunology · doi:10.1111/1348-0421.12285 · Cited by 7
Rescue of internal scaffold-deleted Mason-Pfizer monkey virus particle production by plasma membrane targeting
Sakalian, M., & Rapp, N. D. (2005) · Virology · doi:10.1016/j.virol.2005.09.066 · Cited by 7
Cloning in a plasmid of an MMTV from a wild Chinese mouse: sequencing of the viral LTR
Xu, L., Haga, S., Imai, S., & Sarkar, N. H. (1994) · Virus Research · doi:10.1016/0168-1702(94)90053-1 · Cited by 7
Molecular analysis of a recombinant M-MuLV/RaLV retrovirus
Villanueva, R. A., Campbell, S., & Roth, M. J. (2003) · Virology · doi:10.1016/s0042-6822(03)00518-x · Cited by 6
Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication
Jehad, M. A., Ali, L. M., Pillai, V. N., Prabhu, S. G., Mustafa, F., & Rizvi, T. A. (2026) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaf066 · Cited by 5
Conformational changes of the N-terminal part of Mason-Pfizer monkey virus p12 protein during multimerization
Knejzlı́k, Z., Ulbrich, P., Strohalm, M., Laštůvková, H., Kodı́ček, M., Sakalian, M., & Ruml, T. (2009) · Virology · doi:10.1016/j.virol.2009.07.014 · Cited by 5
Differences and commonalities in plasma membrane recruitment of the two morphogenetically distinct retroviruses HIV-1 and MMTV
Junková, P., Pleskot, R., Prchal, J., Sýs, J., & Ruml, T. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011991 · Cited by 5
Letter to the Editor: Assignment of 1H, 13C, and 15N resonances of WT matrix protein and its R55F mutant from Mason-Pfizer monkey virus
Vlach, J., Lipov, J., Veverka, V., Rumlová, M., Ruml, T., & Hrabal, R. (2005) · Journal of Biomolecular NMR · doi:10.1007/s10858-005-2473-x · Cited by 5
M olecular aspects of the interaction between M ason— P fizer monkey virus matrix protein and artificial phospholipid membrane
Junková, P., Prchal, J., Spiwok, V., Pleskot, R., Kadlec, J., Krásný, L., Hynek, R., Hrabal, R., & Ruml, T. (2016) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.25156 · Cited by 4
Interaction Interface of Mason-Pfizer Monkey Virus Matrix and Envelope Proteins
Prchal, J., Sýs, J., Junková, P., Lipov, J., & Ruml, T. (2020) · Journal of Virology · doi:10.1128/jvi.01146-20 · Cited by 4
Genetic analysis and gene expression of human immunodeficiency virus
Kräusslich, H.-G. (1992) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(05)80327-2 · Cited by 3
The Entire SU Subunit is Required for the Incorporation of the HIV-1 Envelope Glycoprotein Complex into Virions
Li, Y.-Y., & Perez, L. G. (2004) · Virus genes · doi:10.1023/a:1007935927150 · Cited by 1
RNA ‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging
Jehad, M. A., Prabhu, S., Ali, L. M., Pillai, V. N., Mustafa, F., & Rizvi, T. A. (2026) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1002/brv.70188 · Cited by 2
Role of Host Factors in the Subcellular Trafficking of Gag Proteins and Genomic RNA Leading to Virion Assembly
Chen, E. C., & Parent, L. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811185-7.00008-x · Cited by 2
The Morphology and Structure of Viruses
Ruigrok, R. W. H., Schoehn, G., & Conway, J. F. (2010) · Wiley eBooks · doi:10.1002/9780470688618.taw0211 · Cited by 2
HIV-1 Assembly and Cellular Trafficking Pathways: Current Understanding and Potential for Future Therapeutics
Spearman, P. W. (2007) · Future HIV Therapy · doi:10.2217/17469600.1.1.113 · Cited by 2
Development of an efficient and safe integration system for the production of transgenic farm animals
Salmons, B., Günzburg, W. H., Janka, I., & Brem, G. (1996) · Journal of Animal Breeding and Genetics · doi:10.1111/j.1439-0388.1996.tb00630.x · Cited by 2
Host resistance and viral transcription as determinants of MMTV tumorigenesis
Bhadra, S. (2005) · Texas ScholarWorks (Texas Digital Library) · Cited by 1
The Molecular Virology of HIV-1
Montano, M. A., & Williamson, C. E. (2005) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-47817-x_2 · Cited by 1
Betaretroviruses
Voevodin, A. F., & Marx, P. A. (2009) · doi:10.1002/9780813809793.ch6 · Cited by 1
Retroviral Vectors
Collins, M. K., & Porter, C. (1999) · Blood cell biochemistry · doi:10.1007/978-1-4615-4889-8_3 · Cited by 1
Foamy Viruses
Rethwilm, A. (2010) · doi:10.1002/9780470688618.taw0265 · Cited by 1
Regulation of Human Immunodeficiency Virus Structural Protein Expression and Virion Formation
Kräusslich, H. (1993) · Springer eBooks · doi:10.1007/978-1-4615-2928-6_7 · Cited by 1
Envelopment of retrovirus and vaccinia virus
Wallengren, K. (2001) · Figshare
Investigation of the C-Terminal Helix of HIV-1 Matrix: A Region Essential for Multiple Functions in the Viral Life Cycle: A Dissertation
Brandano, L. A. (2011) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/5zmj-9x81
Definition of VPU sensitivity using a model VPU target and role of hydrophobicity of the membrane spanning domain in the viral envelope glycoprotein fusogenicity
Janaka, S. K. (2013) · doi:10.32469/10355/43241
Reconstitution and Characterization of Human Endogenous Retrovirus-K
Lee, Y. N. (2025) · Digital Commons - RU (Rockefeller University) · doi:10.48496/38w4-yp24
New Viruses and Diseases of the Human Central Nervous System
Garson, J. A., & Kerr, J. R. (1999) · Elsevier eBooks · doi:10.1016/b978-012200741-5/50025-8
Histoire évolutive du plus ancien gène d’enveloppe rétrovirale endogène HEMO encore codant chez l’homme, exprimé dans le placenta et les tumeurs : acquisition récente d’une interaction avec une protéase transmembranaire chez les primates
Béguin, A. (2024) · theses.fr (ABES) · doi:10.70675/91026eb5zf996z44a3zad54z8065cd33958b

Authors: Rhee, S. S., & Hunter, E.
Affiliations: University of Alabama at Birmingham (US)
ORCID: Hunter, Eric
Venue: Cell
Publisher: Elsevier BV
Published: 1990-10
Volume: 63
Issue: 1
Pages: 77-86
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(90)90289-q
OpenAlex: W2130138608
Cited by: 160
References: 67
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 2 · 2013: 4
FWCI: 4.30
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA27834)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: capsid assembly, matrix protein, type D retroviruses, type C retroviruses, Mason-Pfizer monkey virus, Gag protein, amino acid substitutions, tryptophan substitution, intracellular trafficking
MeSH terms: Amino Acid Sequence, Animals, Capsid, Cell Line, Clone Cells, HeLa Cells, Molecular Sequence Data, Morphogenesis, Mutation, Retroviridae, Sequence Homology, Nucleic Acid, Transfection, Viral Matrix Proteins, Virion, Gene Products, gag, Betaretrovirus

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A single amino acid substitution within the matrix protein of a type D retrovirus converts its morphogenesis to that of a type C retrovirus

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks