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Cited by 182

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Mouse Hox-2.2 specifies thoracic segmental identity in Drosophila embryos and larvae

Open access
Malicki, Jarema, Schughart, Klaus, McGinnis, William·1990·Cell
DOI 10.1016/0092-8674(90)90499-5
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Abstract

The mouse genome has a number of homeobox genes that are structurally similar to the Drosophila Antenapedia (Antp) gene. We find that one of the mouse Antp-like genes, Hox-2.2, when expressed in developing Drosophila cells under control of a heat shock promoter, can induce homeotic transformations that are nearly identical to those caused by ectopic expression of Antp. In larvae, the Hox-2.2-induced transformations include thoracic denticle belts in place of head structures; in adults, the Hox-2.2 transformations include thoracic legs in place of antennae. The phenotypic effects of Hox-2.2 do not depend on the endogenous Antp gene, whose spatial limits of expression are unaffected by Hox-2.2 expression. Thus, in the Drosophila embryo, Hox-2.2 can substitute for some of the segmental identity functions of Antp, presumably by regulating the same set of downstream genes.

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Metadata

Authors
Malicki, J., Schughart, K., & McGinnis, W.
Venue
Cell
Publisher
Elsevier BV
Published
1990-11
Volume
63
Issue
5
Pages
961-967
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/0092-8674(90)90499-5
OpenAlex
W2118615111
Cited by
182
References
0
FWCI
7.02
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Mouse Hox-2.2 specifies thoracic segmental identity in Drosophila embryos and larvae. https://app.cochat.ai/papers/10.1016/0092-8674(90)90499-5
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Malicki, J., Schughart, K., & McGinnis, W. (1990). Mouse Hox-2.2 specifies thoracic segmental identity in Drosophila embryos and larvae. Cell. https://doi.org/10.1016/0092-8674(90)90499-5

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