The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor
Open accessAbstract
The gene (E2A) for enhancer binding transcription factors E12 and E47 maps to the t(1;19) chromosomal translocation breakpoint in pre-B cell leukemias. Altered E2A transcripts lacking sequences coding for the helix-loop-helix DNA binding motif were detected in several t(1;19)-carrying cell lines. Fusion cDNAs that crossed the t(1;19) breakpoint were cloned and shown to code for an 85 kd protein consisting of the amino-terminal two-thirds of E2A fused to a chromosome 1-derived protein. The fusion protein has the features of a chimeric transcription factor in which the DNA binding domain of E2A is replaced by the putative DNA binding domain of a homeoprotein from chromosome 1 for which the name Prl (pre-B cell leukemia) is proposed. Identical E2A-prl mRNA junctions were detected by PCR in three t(1;19)-carrying cell lines, indicating that the fusion transcripts and predicted chimeric protein are a consistent feature of this translocation.
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Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins
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Cited by
The Hox genes and their roles in oncogenesis
Shah, N., & Sukumar, S. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2826 · Cited by 835
The developmental gene Knotted-1 is a member of a maize homeobox gene family
Vollbrecht, E., Veit, B., Sinha, N., & Hake, S. (1991) · Nature · doi:10.1038/350241a0 · Cited by 759
Chen, Z., Brand, N. J., Chen, A., Chen, S. J., Tong, J. H., Wang, Z. Y., Waxman, S., & Zelent, A. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05757.x · Cited by 640
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Metadata
- Authors
- Nourse, J., Mellentin, J. D., Galili, N., Wilkinson, J., Stanbridge, E., Smith, S. D., & Cleary, M. L.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1990-02
- Volume
- 60
- Issue
- 4
- Pages
- 535-545
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2015828720
- Cited by
- 662
- References
- 3
- FWCI
- 20.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Nourse, J., Mellentin, J. D., Galili, N., Wilkinson, J., Stanbridge, E., Smith, S. D., & Cleary, M. L. (1990). Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell. https://doi.org/10.1016/0092-8674(90)90657-z
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