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Extracellular complementation of a developmental mutation implicates a small sporulation protein in aerial mycelium formation by S. coelicolor
Open accessAbstract
The filamentous bacterium S. coelicolor differentiates by forming aerial hyphae, which protrude into the air and metamorphose into chains of spores. Aerial hyphae formation is associated with the production of a small, abundant protein, SapB, which is present in a zone around colonies of differentiating bacteria. Production of SapB is impaired in bld mutants, which are blocked in aerial hyphae formation, but not in whi mutants in which spore formation is prevented. We report that aerial hyphae formation by a newly identified bld mutant is restored by juxtaposition of the mutant near colonies of SapB-producing bacteria or by the application of the purified protein near mutant colonies. These observations implicate SapB in aerial mycelium formation and suggest that SapB is a morphogenetic protein that enables hyphae on the surface of colonies to grow into the air.
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Citations
Cited by
Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium
Flärdh, K., & Buttner, M. J. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro1968 · Cited by 667
How a fungus escapes the water to grow into the air
Wösten, H. A. B., van Wetter, M.-A., Lugones, L. G., van der Mei, H. C., Busscher, H. J., & Wessels, J. G. H. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80019-0 · Cited by 346
Claessen, D., Rink, R., de Jong, W., Siebring, J., de Vreugd, P., Boersma, F. G. H., Dijkhuizen, L., & Wösten, H. A. B. (2003) · Genes & Development · doi:10.1101/gad.264303 · Cited by 327
Kodani, S., Hudson, M. E., Durrant, M. C., Buttner, M. J., Nodwell, J. R., & Willey, J. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404220101 · Cited by 283
Self-citationSignals and regulators that govern Streptomyces development
McCormick, J. R., & Flärdh, K. (2012) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00317.x · Cited by 265
Metadata
- Authors
- Willey, J., Santamaria, R., Guijarro, J., Geistlich, M., & Losick, R.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1991-05
- Volume
- 65
- Issue
- 4
- Pages
- 641-650
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1985029525
- Cited by
- 176
- References
- 0
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Willey, J., Santamaria, R., Guijarro, J., Geistlich, M., & Losick, R. (1991). Extracellular complementation of a developmental mutation implicates a small sporulation protein in aerial mycelium formation by S. coelicolor. Cell. https://doi.org/10.1016/0092-8674(91)90096-h
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