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oskar mRNA is localized to the posterior pole of the Drosophila oocyte

Open access
Kim-Ha, Jeongsil, Smith, Jeffrey L., Macdonald, Paul M.·1991·Cell

Abstract

Mutants of the maternal posterior-group genes of Drosophila lack posterior body pattern elements and germ cells, both of which form through the action of determinants localized to the posterior pole of the oocyte. We report that transcripts of one of these genes, oskar, become localized to the posterior pole of oocytes shortly after the oocyte begins to differentiate visibly. Analysis of various posterior-group mutants reveals that localization of oskar mRNA is an early step in the posterior localization pathway. In addition, we find that nonsense oskar mutations disrupt osk mRNA localization, while missense oskar mutations do not.

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Metadata

Authors
Kim-Ha, J., Smith, J. L., & Macdonald, P. M.
Venue
Cell
Publisher
Elsevier BV
Published
1991-07
Volume
66
Issue
1
Pages
23-35
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2047040065
Cited by
565
References
2
FWCI
10.27
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: oskar mRNA is localized to the posterior pole of the Drosophila oocyte. https://app.cochat.ai/papers/10.1016/0092-8674(91)90136-m
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Kim-Ha, J., Smith, J. L., & Macdonald, P. M. (1991). oskar mRNA is localized to the posterior pole of the Drosophila oocyte. Cell. https://doi.org/10.1016/0092-8674(91)90136-m

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