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oskar mRNA is localized to the posterior pole of the Drosophila oocyte
Open accessAbstract
Mutants of the maternal posterior-group genes of Drosophila lack posterior body pattern elements and germ cells, both of which form through the action of determinants localized to the posterior pole of the oocyte. We report that transcripts of one of these genes, oskar, become localized to the posterior pole of oocytes shortly after the oocyte begins to differentiate visibly. Analysis of various posterior-group mutants reveals that localization of oskar mRNA is an early step in the posterior localization pathway. In addition, we find that nonsense oskar mutations disrupt osk mRNA localization, while missense oskar mutations do not.
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The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins
Landschulz, W. H., Johnson, P. F., & McKnight, S. L. (1988) · Science · doi:10.1126/science.3289117 · Cited by 3,443
Cited by
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Mammalian Staufen1 Recruits Upf1 to Specific mRNA 3′UTRs so as to Elicit mRNA Decay
Kim, Y. K., Furic, L., DesGroseillers, L., & Maquat, L. E. (2005) · Cell · doi:10.1016/j.cell.2004.11.050 · Cited by 494
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Gavis, E. R., & Lehmann, R. (1992) · Cell · doi:10.1016/0092-8674(92)90358-j · Cited by 391
Metadata
- Authors
- Kim-Ha, J., Smith, J. L., & Macdonald, P. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1991-07
- Volume
- 66
- Issue
- 1
- Pages
- 23-35
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2047040065
- Cited by
- 565
- References
- 2
- FWCI
- 10.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: oskar mRNA is localized to the posterior pole of the Drosophila oocyte. https://app.cochat.ai/papers/10.1016/0092-8674(91)90136-m
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- Kim-Ha, J., Smith, J. L., & Macdonald, P. M. (1991). oskar mRNA is localized to the posterior pole of the Drosophila oocyte. Cell. https://doi.org/10.1016/0092-8674(91)90136-m
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