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Crystal structure of a MATα2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions
Open accessAbstract
The MAT alpha 2 homeodomain regulates the expression of cell type-specific genes in yeast. We have determined the 2.7 A resolution crystal structure of the alpha 2 homeodomain bound to a biologically relevant DNA sequence. The DNA in this complex is contacted primarily by the third of three alpha-helices, with additional contacts coming from an N-terminal arm. Comparison of the yeast alpha 2 and the Drosophila engrailed homeodomain-DNA complexes shows that the protein fold is highly conserved, despite a 3-residue insertion in alpha 2 and only 27% sequence identity between the two homeodomains. Moreover, the orientation of the recognition helix on the DNA is also conserved. This docking arrangement is maintained by side chain contacts with the DNA--primarily the sugar-phosphate backbone--that are identical in alpha 2 and engrailed. Since these residues are conserved among all homeodomains, we propose that the contacts with the DNA are also conserved and suggest a general model for homeodomain-DNA interactions.
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Citations
Cites
A regulatory hierarchy for cell specialization in yeast
Herskowitz, I. (1989) · Nature · doi:10.1038/342749a0 · Cited by 590
Cited by
Ellenberger, T. E., Brandl, C. J., Struhl, K., & Harrison, S. C. (1992) · Cell · doi:10.1016/s0092-8674(05)80070-4 · Cited by 972
Schwabe, J. W. R., Chapman, L., Finch, J. T., & Rhodes, D. (1993) · Cell · doi:10.1016/0092-8674(93)90390-c · Cited by 750
Lincoln, C., Long, J., Yamaguchi, J., Serikawa, K., & Hake, S. (1994) · The Plant Cell · doi:10.1105/tpc.6.12.1859 · Cited by 657
Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box.
Kiledjian, M., & Dreyfuss, G. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05331.x · Cited by 629
Klemm, J. D., Rould, M. A., Aurora, R., Herr, W., & Pabo, C. O. (1994) · Cell · doi:10.1016/0092-8674(94)90231-3 · Cited by 506
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Metadata
- Authors
- Wolberger, C., Vershon, A. K., Liu, B., Johnson, A. D., & Pabo, C. O.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1991-11
- Volume
- 67
- Issue
- 3
- Pages
- 517-528
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2046278558
- Cited by
- 524
- References
- 1
- FWCI
- 21.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Crystal structure of a MATα2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions. https://app.cochat.ai/papers/10.1016/0092-8674(91)90526-5
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- Wolberger, C., Vershon, A. K., Liu, B., Johnson, A. D., & Pabo, C. O. (1991). Crystal structure of a MATα2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions. Cell. https://doi.org/10.1016/0092-8674(91)90526-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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