Messenger RNA degradation in eukaryotes
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Retroviruses use the host transcriptional machinery to transcribe, cap, and polyadenylate viral mRNAs at the 3′ end, including gRNA.
“Retroviruses use the host transcriptional machinery to transcribe, cap [add a methyl guanosine (G) group at the 5′ end], and polyadenylate viral mRNAs at the 3′ end, including gRNA.”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Sachs 1993
In a eukaryotic cell, capping and polyadenylation are obligatorily required for nuclear export of RNAs and their subsequent translation.
“In a eukaryotic cell, all these steps are obligatorily required for nuclear export of the RNAs and their subsequent translation (Jackson and Standart 1990, Eckner et al. 1991, Sachs 1993).”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Sachs 1993
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References 72 · Cited by 846
- Authors
- Sachs, A. B.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Sachs, Alan B.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1993-08
- Volume
- 74
- Issue
- 3
- Pages
- 413-421
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1971421846
- Cited by
- 846
- References
- 72
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 7 · 2018: 7 · 2017: 6 · 2016: 6 · 2015: 10 · 2014: 5 · 2013: 4 · 2012: 9
- FWCI
- 12.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29gm043164-02)
- National Institute of General Medical Sciences (R29 GM43164)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- mRNA degradation, mRNA, eukaryotic gene expression, RNA turnover, post-transcriptional regulation
- MeSH terms
- Animals, Base Sequence, Eukaryotic Cells, Models, Structural, Molecular Sequence Data, Nucleic Acid Conformation, Poly A, RNA, RNA, Messenger, Saccharomyces cerevisiae, Protein Biosynthesis, Open Reading Frames
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