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Control of cell pattern in the neural tube: Regulation of cell differentiation by dorsalin-1, a novel TGFβ family member
Open accessAbstract
Distinct cell types differentiate along the dorsoventral axis of the neural tube. We have cloned and characterized a novel member of the TGF beta gene family, dorsalin-1 (dsl-1), that appears to regulate cell differentiation within the neural tube. dsl-1 is expressed selectively in the dorsal neural tube, and its pattern of expression appears to be restricted by early signals from the notochord. Exposure of neural plate cells to dsl-1 promotes the differentiation of cells with neural crest-like properties and inhibits the induction of motor neurons by signals from the notochord and floor plate. These findings suggest that dsl-1 regulates the differentiation of cell types along the dorsoventral axis of the neural tube, acting in conjunction with distinct ventralizing signals from the notochord and floor plate.
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Cited by
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Roelink, H., Augsburger, A., Heemskerk, J., Korzh, V., Norlin, S., Ruiz i Altaba, A., Tanabe, Y., Placzek, M., Edlund, T., Jessell, T. M., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90514-2 · Cited by 854
Self-citationLaufer, E., Nelson, C. E., Johnson, R. L., Morgan, B. A., & Tabin, C. (1994) · Cell · doi:10.1016/0092-8674(94)90030-2 · Cited by 803
Notochord repression of endodermal Sonic hedgehog permits pancreas development
Hebrok, M., Kim, S. K., & Melton, D. A. (1998) · Genes & Development · doi:10.1101/gad.12.11.1705 · Cited by 628
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Metadata
- Authors
- Basler, K., Edlund, T., Jessell, T. M., & Yamada, T.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1993-05
- Volume
- 73
- Issue
- 4
- Pages
- 687-702
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2065200502
- Cited by
- 319
- References
- 0
- FWCI
- 15.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Control of cell pattern in the neural tube: Regulation of cell differentiation by dorsalin-1, a novel TGFβ family member. https://app.cochat.ai/papers/10.1016/0092-8674(93)90249-p
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- Basler, K., Edlund, T., Jessell, T. M., & Yamada, T. (1993). Control of cell pattern in the neural tube: Regulation of cell differentiation by dorsalin-1, a novel TGFβ family member. Cell. https://doi.org/10.1016/0092-8674(93)90249-p
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
