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Conformational states of CFTR associated with channel gating: The role of ATP binding and hydrolysis
Open accessAbstract
CFTR is a member of the traffic ATPase superfamily and a Cl- ion channel that appears to require ATP hydrolysis for gating. Analysis of single CFTR Cl- channels reconstituted into planar lipid bilayers revealed the presence of two open conductance states that are connected to each other and to the closed state by an asymmetric cycle of gating events. We show here that the transition between the two open conductance states is directly coupled to ATP hydrolysis by one of the consensus nucleotide-binding folds, designated NBF2. Moreover, the transition between the closed state and one of the open states is linked to the binding of ATP. This analysis permits real-time visualization of conformational changes associated with a single cycle of ATP hydrolysis by a single protein molecule and suggests a model describing a role for ATP in CFTR gating.
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Citations
Cited by
Structure and Function of the CFTR Chloride Channel
SHEPPARD, D. N., & WELSH, M. J. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.s23 · Cited by 1,018
CFTR Function and Prospects for Therapy
Riordan, J. R. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142532 · Cited by 610
Molecular Structure of the Human CFTR Ion Channel
Liu, F., Zhang, Z., Csanády, L., Gadsby, D. C., & Chen, J. (2017) · Cell · doi:10.1016/j.cell.2017.02.024 · Cited by 523
CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains
Vergani, P., Lockless, S. W., Nairn, A. C., & Gadsby, D. C. (2005) · Nature · doi:10.1038/nature03313 · Cited by 416
Physiological Basis of Cystic Fibrosis: A Historical Perspective
QUINTON, P. M. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.s3 · Cited by 405
Metadata
- Authors
- Gunderson, K. L., & Kopito, R. R.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1995-07
- Volume
- 82
- Issue
- 2
- Pages
- 231-239
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2059043844
- Cited by
- 229
- References
- 0
- FWCI
- 18.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Gunderson, K. L., & Kopito, R. R. (1995). Conformational states of CFTR associated with channel gating: The role of ATP binding and hydrolysis. Cell. https://doi.org/10.1016/0092-8674(95)90310-0
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