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Cited by 278

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Different forms of TFIIH for transcription and DNA repair: Holo-TFIIH and a nucleotide excision repairosome

Open access
Svejstrup, Jesper Q, Wang, Zhigang, Feave, William J, Wu, Xiahua, Bushnell, David A, Donahue, Thomas F, Friedberg, Errol C, Kornberg, Roger D·1995·Cell

Abstract

Yeast TFIIH that is active in transcription can be dissociated into three components: a 5-subunit core, the SSL2 gene product, and a complex of 47 kDa, 45 kDa, and 33 kDa polypeptides that possesses protein kinase activity directed towards the C-terminal repeat domain of RNA polymerase II. These three components can reconstitute fully functional TFIIH, and all three are required for transcription in vitro. By contrast, TFIIH that is highly active in nucleotide excision repair (NER) lacks the kinase complex and instead contains the products of all other genes known to be required for NER in yeast: RAD1, RAD2, RAD4, RAD10, and RAD14. This repairosome is not active in reconstituted transcription in vitro and is significantly more active than any of the constituent polypeptides in correcting defective repair in extracts from strains mutated in NER genes.

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Metadata

Authors
Svejstrup, J. Q., Wang, Z., Feave, W. J., Wu, X., Bushnell, D. A., Donahue, T. F., Friedberg, E. C., & Kornberg, R. D.
Venue
Cell
Publisher
Elsevier BV
Published
1995-01
Volume
80
Issue
1
Pages
21-28
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2039068784
Cited by
278
References
53
FWCI
14.09
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Different forms of TFIIH for transcription and DNA repair: Holo-TFIIH and a nucleotide excision repairosome. https://app.cochat.ai/papers/10.1016/0092-8674(95)90447-6
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Svejstrup, J. Q., Wang, Z., Feave, W. J., Wu, X., Bushnell, D. A., Donahue, T. F., Friedberg, E. C., & Kornberg, R. D. (1995). Different forms of TFIIH for transcription and DNA repair: Holo-TFIIH and a nucleotide excision repairosome. Cell. https://doi.org/10.1016/0092-8674(95)90447-6

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