The DOI matches its Crossref record.
Ectopic expression of the flagellar regulon alters development of the bordetella-host interaction
Open accessAbstract
Signal transduction molecules within the two-component family represent a conserved adaptation for the control of genes involved in pathogenesis. The Bordetella virulence control locus, bvgAS, activates and represses gene expression in response to environmental signals. While infection requires virulence gene activation, the role of gene repression during infection is not understood. By altering regulatory genes and reversing regulatory connections, we found evidence that the BvgAS-repressed genes responsible for motility are neither required nor expressed during colonization of the host. Expression of this Bvg- phase-specific phenotype in the Bvg+ growth phase resulted in a defect in tracheal colonization. Therefore, BvgAS promotes virulence both by activating genes required for colonization and by repressing genes that inhibit the development of infection.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
The role of motility as a virulence factor in bacteria
Josenhans, C., & Suerbaum, S. (2002) · International Journal of Medical Microbiology · doi:10.1078/1438-4221-00173 · Cited by 658
Role of Flagella in Pathogenesis of Pseudomonas aeruginosa Pulmonary Infection
Feldman, M., Bryan, R., Rajan, S., Scheffler, L., Brunnert, S., Tang, H., & Prince, A. (1998) · Infection and Immunity · doi:10.1128/iai.66.1.43-51.1998 · Cited by 490
Boyd, D., Peters, G. A., Cloeckaert, A., Boumedine, K. S., Chaslus-Dancla, E., Imberechts, H., & Mulvey, M. R. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.19.5725-5732.2001 · Cited by 414
Regulation cascade of flagellar expression in Gram-negative bacteria
Soutourina, O. A., & Bertin, P. N. (2003) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(03)00064-0 · Cited by 363
Use of model plant hosts to identify Pseudomonas aeruginosa virulence factors
Rahme, L. G., Tan, M.-W., Le, L., Wong, S. M., Tompkins, R. G., Calderwood, S. B., & Ausubel, F. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13245 · Cited by 300
Metadata
- Authors
- Akerley, B. J., Cotter, P. A., & Miller, J. F.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1995-02
- Volume
- 80
- Issue
- 4
- Pages
- 611-620
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2070318111
- Cited by
- 252
- References
- 0
- FWCI
- 7.30
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Ectopic expression of the flagellar regulon alters development of the bordetella-host interaction. https://app.cochat.ai/papers/10.1016/0092-8674(95)90515-4
- The paper
- Akerley, B. J., Cotter, P. A., & Miller, J. F. (1995). Ectopic expression of the flagellar regulon alters development of the bordetella-host interaction. Cell. https://doi.org/10.1016/0092-8674(95)90515-4
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
