5 α-reductase activity in polycystic ovary syndrome
Abstract
11 patients with polycystic ovary syndrome (hirsutism and oligomenorrhoea), but with no deficiency of 21-hydroxylase or 3 beta-hydroxysteroid dehydrogenase, had abnormal cortisol metabolism. The high ratio of 5 alpha to 5 beta cortisol metabolites in the urine is consistent with enhanced activity of 5 alpha-reductase. Urinary total cortisol metabolites were higher in patients than controls. Increased 5 alpha-reductase activity in liver and skin enhances hepatic cortisol metabolism at the expense of androgen excess and may be the underlying abnormality in polycystic ovary syndrome.
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Systemic upregulation of 5α-reductase activity is observed in women with PCOS leading to enhanced glucocorticoid clearance and enhanced androgen activation in peripheral tissues.
“Systemic upregulation of 5α-reductase activity is observed in women with PCOS leading to enhanced glucocorticoid clearance and enhanced androgen activation in peripheral tissues (Fassnacht et al., 2003, Stewart et al., 1990, Vassiliadi et al., 2009)”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Stewart et al., 1990
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References 24 · Cited by 189
- Authors
- Stewart, P. M., Edwards, C. R. W., Shackleton, C. H. L., & Beastall, G. H.
- Affiliations
- Western General Hospital (GB)
- Glasgow Royal Infirmary (GB)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1990-02
- Volume
- 335
- Issue
- 8687
- Pages
- 431-433
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2096677248
- Cited by
- 189
- References
- 24
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 11 · 2015: 6 · 2014: 10 · 2013: 6 · 2012: 5
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- polycystic ovary syndrome, 5α-reductase, cortisol metabolism, urinary cortisol metabolites, hyperandrogenism, hirsutism, oligomenorrhea, skin
- MeSH terms
- Adrenocorticotropic Hormone, Adult, Androstenedione, Androsterone, Cortisone, Etiocholanolone, Female, Humans, Hydrocortisone, Injections, Intramuscular, Luteinizing Hormone, Liver, Polycystic Ovary Syndrome, Skin, Testosterone, 3-Oxo-5-alpha-Steroid 4-Dehydrogenase, Time Factors
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