Hyperinsulinaemia in thyrotoxic hypokalaemic periodic paralysis
Abstract
To test the hypothesis that there is an abnormal serum insulin response to a carbohydrate load in thyrotoxic hypokalaemic periodic paralysis (THPP), 18 men with THPP and 15 with uncomplicated thyrotoxicosis were studied during an oral glucose tolerance test. The THPP group had significantly higher fasting insulin concentrations (27.6 [3.6] vs 13.4 [1.8] mU/l; p less than 0.005) and a higher overall insulin response to oral glucose (p less than 0.001 by ANOVA) than the thyrotoxicosis group. There were no significant differences in fasting or stimulated glucose. Hyperinsulinaemia may be an important factor in the precipitation of acute paralysis in THPP.
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Hyperinsulinemia is observed during acute attacks of TPP and TPP patients have exaggerated insulin responses to oral glucose challenge compared with patients with pure hyperthyroidism.
“The role of insulin in TPP was revealed by the finding that hyperinsulinemia was observed during acute attacks of TPP and that TPP patients had exaggerated insulin responses to oral glucose challenge in comparison with patients with pure hyperthyroidism (17, 18, 19).”
From A 10-year analysis of thyrotoxic periodic paralysis in 135 patients: focus on symptomatology and precipitants (2013) · cites this paper as [17]
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References 11 · Cited by 69
- Authors
- Lee, K. O., Taylor, E. A., Oh, V. M. S., Cheah, J. S., & Aw, S. E.
- Affiliations
- National University of Singapore (SG)
- Singapore General Hospital (SG)
- Corresponding author
- Lee, K.O.
- ORCID
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1991-05
- Volume
- 337
- Issue
- 8749
- Pages
- 1063-1064
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2113872117
- Cited by
- 69
- References
- 11
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 4
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Potassium and Related Disorders
- Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
- Keywords
- hyperinsulinemia, insulin response to glucose, thyrotoxicosis, fasting insulin, oral glucose tolerance test, hypokalemia, acute paralysis
- MeSH terms
- Acute Disease, Adult, Analysis of Variance, Blood Glucose, Glucose Tolerance Test, Humans, Hypokalemia, Insulin, Male, Paralysis, Thyrotoxicosis
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