Detection of premature atherosclerosis by high-resolution ultrasonography in symptom-free hypopituitary adults
Abstract
Retrospective analysis suggests that there is increased mortality from vascular disease in hypopituitary adults, but vascular status before death is unknown. High resolution B-mode ultrasonic imaging of both carotid and femoral arteries was therefore done in 34 adult hypopituitary patients on routine replacement therapy and was compared with that in 39 matched controls. Changes were related to risk factors for vascular disease. Carotid intima-media thickness was greater in patients than in controls (mean [SD] 0.74 [0.16] vs 0.65 [0.13] mm, p < 0.02). This difference was seen in middle-aged and elderly patients. More patients than controls had one or more atheromatous plaques (65% vs 41%, p < 0.05). The percentage of individual arteries with a plaque was also higher in patients (32% vs 18%, p < 0.005). In multiple regression analysis, patients' age was the dominant factor determining carotid intima-media thickness. Symptom-free adults with hypopituitarism show an increased prevalence of atherosclerosis.
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Altered body composition, insulin resistance, hypertension, unfavorable lipid profile, endothelial dysfunction and atherosclerosis have been found in several studies on patients with long-term GHD.
“Altered body composition, insulin resistance, hypertension, unfavorable lipid profile, endothelial dysfunction and atherosclerosis have been found in several studies on patients with long-term GHD (74,76,77,(82)(83)(84)(85)(86)(87).”
From Pituitary Dysfunction After Traumatic Brain Injury: A Clinical and Pathophysiological Approach (2015) · cites this paper as [85]
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References 25 · Cited by 390
- Authors
- Markussis, V., Beshyah, S. A., Johnston, D. G., Fisher, C., Nicolaides, A. N., & Sharp, P.
- Affiliations
- St Mary's Hospital (GB)
- Northwick Park Hospital (GB)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1992-11
- Volume
- 340
- Issue
- 8829
- Pages
- 1188-1192
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2126784809
- Cited by
- 390
- References
- 25
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 5 · 2022: 2 · 2020: 3 · 2019: 3 · 2018: 7 · 2017: 5 · 2016: 2 · 2015: 9 · 2014: 7 · 2013: 5 · 2012: 10
- FWCI
- 8.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
- Keywords
- hypopituitarism, atherosclerosis, carotid intima-media thickness, atherosclerotic plaque, carotid artery, femoral artery, vascular risk factors, premature atherosclerosis, vascular death
- MeSH terms
- Adult, Age Factors, Aged, Arteriosclerosis, Blood Glucose, Cholesterol, Female, Femoral Artery, Humans, Hypopituitarism, Male, Middle Aged, Risk Factors, Ultrasonography, Case-Control Studies, Carotid Artery, Common
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