Photodynamic therapy of oral cancer: photosensitisation with systemic aminolaevulinic acid
Abstract
Photodynamic therapy with intravenous photosensitising drugs has been shown to be effective in the ablation of superficial cancers, but long-lasting photosensitivity is a serious disadvantage. Similar photosensitivity is a feature of certain types of porphyria. We present the first report of tumour necrosis brought about by photodynamic activation of a temporary endogenous porphyrin accumulation, after an oral dose of the haem precursor, 5-aminolaevulinic acid. In 4 patients, quantitative fluorescence microscopy showed that accumulation of the photoactive intermediate protoporphyrin IX peaked after 4-6 h in 4 oral cavity squamous cell carcinomas, returning to background in 24 h. Irradiation with non-thermal red laser light caused tumour necrosis in 3 patients.
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ALA-PDT was shown to be an effective treatment for head and neck cancer, especially for superficial lesions.
“Moreover, ALA-PDT was shown to be an effective treatment for head and neck cancer, especially for superficial lesions [119].”
From Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer (2011) · cites this paper as [119]
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Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer
Wachowska, M., Muchowicz, A., Firczuk, M., Gabrysiak, M., Winiarska, M., Wańczyk, M., Bojarczuk, K., & Golab, J. (2011) · Molecules · doi:10.3390/molecules16054140 · Cited by 265 · see citing works
Gibson, S., Cupriks, D., Havens, J., Nguyen, M., & Hilf, R. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.39 · Cited by 78 · see citing works
Inoue, H., Kajimoto, Y., Shibata, M.-A., Miyoshi, N., Ogawa, N., Miyatake, S.-I., Otsuki, Y., & Kuroiwa, T. (2007) · Journal of Neuro-Oncology · doi:10.1007/s11060-006-9325-8 · Cited by 50 · see citing works
- Authors
- Grant, W. E., MacRobert, A., Bown, S. G., Hopper, C., & Speight, P. M.
- Affiliations
- University College London (GB)
- Eastman Dental Hospital (GB)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1993-07
- Volume
- 342
- Issue
- 8864
- Pages
- 147-148
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2109966571
- Cited by
- 263
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 6 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 6 · 2015: 8 · 2014: 7 · 2013: 9 · 2012: 6
- FWCI
- 19.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- photodynamic therapy, oral cancer, 5-aminolevulinic acid, photosensitization, protoporphyrin IX, endogenous porphyrins, squamous cell carcinoma, tumor necrosis, red laser irradiation, porphyria
- MeSH terms
- Administration, Oral, Aminolevulinic Acid, Carcinoma, Squamous Cell, Fluorescence, Humans, Mouth Neoplasms, Necrosis, Palliative Care, Photochemotherapy, Protoporphyrins, Photosensitizing Agents, Laser Therapy
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