Biodegradable lysine diisocyanate-based poly(glycolide-co-ϵ-caprolactone)-urethane network in artificial skin
Abstract
A biodegradable lysine diisocyanate-based poly(glycolide-co-epsilon-caprolactone)urethane network has been evaluated as a material for the construction of a macroporous bottom layer (dermal analogue) in a two-layer artificial skin. High rates of in vitro degradation were observed; degradation of the porous poly(glycolide-co-epsilon-caprolactone)urethane networks was faster in vivo than in vitro. Subcutaneous implantation in guinea pigs showed that the porous polyurethane networks allowed rapid cell ingrowth, degraded almost completely 4-8 wk after implantation and evoked no adverse tissue reaction.
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The degradation of the artificial skin in vivo was faster than that in vitro.
“The degradation of the skin in-vivo was faster than that in in-vitro.”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Bruin et al., 1990
Subcutaneous implantation in guinea pigs showed that porous polyurethane networks allowed rapid cell in-growth, degraded almost completely 4-8 weeks after implantation and evoked no adverse tissue reaction.
“Subcutaneous implantation in guinea pigs showed that the porous polyurethane networks allowed rapid cell in-growth, degraded almost completely 4-8 weeks after implantation and evoked no adverse tissue reaction.”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Bruin et al., 1990
Polyurethane networks based on LDI and poly(glycolide-co-γ-caprolactone) macrodiol were evaluated by Bruin et al. as two-layer artificial skin.
“Polyurethane networks based on LDI and poly(glycolide-co-γ-caprolactone) macrodiol was evaluated by Bruin et al. (1990) as two-layer artificial skin.”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Bruin et al., 1990
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Biodegradable synthetic polymers for tissue engineering
CSIRO Molecular Science, B. 1., & Gunatillake, P. (2003) · European Cells and Materials · doi:10.22203/ecm.v005a01 · Cited by 1,765 · see citing works
“Polyurethane networks based on LDI and poly(glycolide-co-γ-caprolactone) macrodiol was evaluated by Bruin et al. (1990) as two-layer artificial skin.”
MethodSynthesis of two-component injectable polyurethanes for bone tissue engineering
Bonzani, I. C., Adhikari, R., Houshyar, S., Mayadunne, R., Gunatillake, P., & Stevens, M. M. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.08.026 · Cited by 159 · see citing works
McBane, J. E., Matheson, L. A., Sharifpoor, S., Santerre, J. P., & Labow, R. S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.07.010 · Cited by 63 · see citing works
Knight, P. T., Kirk, J. T., Anderson, J. M., & Mather, P. T. (2010) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32806 · Cited by 27 · see citing works
- Authors
- Bruin, P., Smedinga, J., Pennings, A. J., & Jonkman, M. F.
- Affiliations
- University of Groningen (NL)
- University Medical Center Groningen (NL)
- Corresponding author
- Pennings, A.J.
- ORCID
- Jonkman, M.F.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 1990-05
- Volume
- 11
- Issue
- 4
- Pages
- 291-295
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2125899536
- Cited by
- 76
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 2 · 2013: 1 · 2012: 4
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Keywords
- polyurethane, biodegradable polymers, artificial skin, macroporous scaffolds, in vitro degradation, in vivo degradation, subcutaneous implantation, cell infiltration, tissue reaction
- MeSH terms
- Animals, Artificial Organs, Biocompatible Materials, Biodegradation, Environmental, Cyanates, Guinea Pigs, Lysine, Materials Testing, Microscopy, Electron, Scanning, Polyesters, Skin, Prostheses and Implants
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