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Selective placental transport of maternal IgG to the fetus
Abstract
During pregnancy there is a dramatic reduction in the serum levels of agalactosyl IgG (G0IgG) in both normal women and those with rheumatoid arthritis. In order to determine if a similar reduction in G0IgG were apparent in fetal serum, a comparison of the galactose content of IgG from nine paired samples of umbilical vein or fetal blood and peripheral maternal serum, at gestational ages ranging from 16-41 weeks was performed. The full-term maternal IgG samples were highly galactosylated, so confirming previous observations of reduced G0IgG levels during pregnancy. In addition every paired sample of fetal IgG had a higher level of galactosylation than the corresponding maternal IgG. Therefore, during pregnancy there is both a reduced biosynthesis of the G0IgG glycoform by the mother, and a restriction of its transport across the placenta. The ratio of estimated G0IgG in fetal and maternal serum was found to be related to changes in IgG transport, and in particular the active transport of IgG1 across the placenta during gestation. Our data suggest that the placental IgG transport mechanism is either carbohydrate independent by discriminating for IgG1, or is carbohydrate dependent selecting for highly galactosylated IgG glycoforms. This study emphasizes the need for further investigations on the biological function of G0IgG in normal physiological states, in addition to disease states, such as juvenile and adult rheumatoid arthritis, where elevated G0IgG levels correlate with di…
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Studies in the 1990s demonstrated reduced concentrations of non-glycosylated IgG and higher concentrations of galactosylated IgG in newborn infants.
“studies in the 1990s, which demonstrated reduced concentrations of non-glycosylated IgG and higher concentrations of galactosylated IgG in newborn infants (85, 86).”
From Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy (2017) · cites this paper as [85]
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Research works printed but not linked: 17
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Wilcox, C. R., Holder, B., & Jones, C. E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01294 · Cited by 200
“Supportive evidence for the hypothesis of preferential transport of glycosylated IgG comes from studies in the 1990s, which demonstrated reduced concentrations of nonglycosylated IgG and higher concentrations of galactosylated IgG in newborn infants (85, 86).”
Metadata
- Authors
- Williams, P. J., Arkwright, P. D., Rudd, P., Scragg, I. G., Edge, C. J., Wormald, M. R., & Rademacher, T. W.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Rademacher, T.W.
- Venue
- Placenta
- Publisher
- Elsevier BV
- Published
- 1995-12
- Volume
- 16
- Issue
- 8
- Pages
- 749-756
- ISSN
- 0143-4004 (ISSN-L)
- OpenAlex
- W2089226988
- Cited by
- 58
- References
- 0
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 5
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Placenta (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Keywords
- agalactosyl IgG, IgG glycosylation, galactose, maternal IgG, IgG1, rheumatoid arthritis, pregnancy, umbilical cord blood
- MeSH terms
- Arthritis, Rheumatoid, Biological Transport, Female, Fetal Blood, Gestational Age, Glycosylation, Humans, Immunoglobulin G, Maternal-Fetal Exchange, Placenta, Pregnancy, Case-Control Studies
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