Selective attenuation of cocaine-induced stereotyped behaviour by oxytocin: Putative role of basal forebrain target sites
Abstract
The effects of oxytocin (OXT), arginine- and lysine-vasopressin (AVP and LVP) and an OXT-receptor antagonist on cocaine-induced sniffing behaviour were investigated in rats. OXT, but not AVP or LVP injected subcutaneously (s.c.) attenuated cocaine-induced sniffing. The effect of OXT (s.c.) was inhibited by an OXT-receptor antagonist administered intracerebroventricularly (i.c.v.). I.c.v. administration of different doses of OXT in nanogram quantities caused a dose-dependent attenuation of cocaine-induced sniffing. Local cerebral microinjection of OXT into the accumbens nucleus and olfactory tubercle but not into the olfactory nucleus, central amygdaloid nucleus or caudate nucleus, inhibited the cocaine-induced sniffing behaviour. These results demonstrate that OXT selectively attenuates the cocaine-induced stereotyped behaviour through basal forebrain target sites.
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Exogenous OT attenuates many immediate behavioral effects of drugs of abuse, including reducing drug consumption, with some effects localized to the NAC.
“Exogenous OT attenuates many of the immediate behavioral effects of drugs of abuse, including reducing drug consumption, and some of the attenuating effects of OT are localized to the NAC (Kovacs et al 1990; Sarnyai et al 1990; Sarnyai et al 1991; Qi et al 2009; Carson et al 2010a; Baracz et al 2012).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Sarnyai et al 1991
In rodent models of drug use, oxytocin reduces reinforcement and drug-seeking behavior.
“In rodent models of drug use, it has been suggested that oxytocin reduces reinforcement and drug-seeking behavior (Carson et al., 2010; Kovacs et al., 1998; Sarnyai et al., 1991; Sarnyai et al., 1992)”
From Effect of oxytocin on craving and stress response in marijuana-dependent individuals: A pilot study (2013) · cites this paper as Sarnyai et al., 1991
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References 30 · Cited by 71
- Authors
- Sarnyai, Z., Babarczy, E., Kriván, M., Szabó, G., Kovács, G. L., Barth, T., & Telegdy, G.
- Affiliations
- University of Szeged (HU)
- Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry (CZ)
- Corresponding author
- Sarnyai, Z.
- Venue
- Neuropeptides
- Publisher
- Elsevier BV
- Published
- 1991-05
- Volume
- 19
- Issue
- 1
- Pages
- 51-56
- ISSN
- 0143-4179 (ISSN-L)
- OpenAlex
- W2069219662
- Cited by
- 71
- References
- 30
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 9 · 2015: 1 · 2014: 4 · 2013: 7 · 2012: 4
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropeptides (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, cocaine, stereotypy, sniffing, vasopressin, lysine vasopressin, oxytocin receptor antagonist, nucleus accumbens, olfactory tubercle, central amygdala, caudate nucleus, basal forebrain
- MeSH terms
- Animals, Arginine Vasopressin, Cocaine, Diencephalon, Injections, Intraventricular, Lypressin, Male, Microinjections, Oxytocin, Rats, Inbred Strains, Stereotyped Behavior, Telencephalon, Rats
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