Effects of phototherapy on non-seasonal unipolar and bipolar depressive spectrum disorders
Abstract
In a group of 17 patients with non-SAD depressive disorders we compared the response of bipolar spectrum versus unipolar patients to treatment with light therapy. The main hypothesis was that bipolar spectrum depressed patients would preferentially respond to bright light therapy as compared to unipolar depressed patients. All patients were treated with either 400 or 2500 lux phototherapy for 2 h on seven consecutive days. All outcome measures, which included the SIGH-SAD, CGI, and the Anxiety and Depressive Factors of the SCL-90, showed significant improvement in the bipolar vs. the unipolar spectrum patients. Unexpected this occurred regardless of the intensity of the light. These changes were judged to be quite clinically significant. All patients showing response were noted to have maintained their response at a 3-month follow-up.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
An open-label study found that 400 lux (low intensity light) for 2 hr could be effective for treating bipolar depression.
“an open‐label study found 400 lux (low intensity light) for 2 hr could be effective for treating bipolar depression (Deltito et al., 1991).”
From Adjunctive bright light therapy for treating bipolar depression: A systematic review and meta‐analysis of randomized controlled trials (2020) · cites this paper as Deltito et al., 1991
Cites
Antidepressant effects of light in seasonal affective disorder
(1985) · American Journal of Psychiatry · doi:10.1176/ajp.142.2.163 · Cited by 339 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Lieverse, R., Van Someren, E. J. W., Nielen, M. M. A., Uitdehaag, B. M. J., Smit, J. H., & Hoogendijk, W. J. G. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.183 · Cited by 261 · see citing works
Light therapy for non-seasonal depression
Tuunainen, A., Kripke, D. F., & Endo, T. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004050.pub2 · Cited by 261 · see citing works
Bright light therapy for nonseasonal depression: meta-analysis of clinical trials
Al-Karawi, D., & Jubair, L. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.03.016 · Cited by 189 · see citing works
Benca, R. M., Okawa, M., Uchiyama, M., Ozaki, S., Nakajima, T., Shibui, K., & Obermeyer, W. H. (1997) · Sleep Medicine Reviews · doi:10.1016/s1087-0792(97)90005-8 · Cited by 165 · see citing works
Stephenson, K. M., Schroder, C. M., Bertschy, G., & Bourgin, P. (2012) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2011.09.002 · Cited by 140 · see citing works
Light therapy for bipolar disorder: a case series in women
Sit, D., Wisner, K. L., Hanusa, B. H., Stull, S., & Terman, M. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00451.x · Cited by 127 · see citing works
Bright light as a personalized precision treatment of mood disorders
Maruani, J., & Geoffroy, P. A. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00085 · Cited by 112 · see citing works
Light therapy in the treatment of patients with bipolar depression: A meta-analytic study
Tseng, P.-T., Chen, Y.-W., Tu, K.-Y., Chung, W., Wang, H.-Y., Wu, C.-K., & Lin, P.-Y. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.03.001 · Cited by 100 · see citing works
Dauphinais, D. R., Rosenthal, J. Z., Terman, M., DiFebo, H. M., Tuggle, C., & Rosenthal, N. E. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.01.015 · Cited by 63 · see citing works
Hirakawa, H., Terao, T., Muronaga, M., & Ishii, N. (2020) · Brain and Behavior · doi:10.1002/brb3.1876 · Cited by 61 · see citing works
Efficacy of bright light therapy in bipolar depression
Yorguner Kupeli, N., Bulut, N. S., Carkaxhiu Bulut, G., Kurt, E., & Kora, K. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2017.12.020 · Cited by 51 · see citing works
Lee, H.-J., Son, G.-H., & Geum, D. (2013) · Psychiatry Investigation · doi:10.4306/pi.2013.10.3.225 · Cited by 48 · see citing works
Rate of switch from bipolar depression into mania after morning light therapy: A historical review
Benedetti, F. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.01.013 · Cited by 39 · see citing works
A sham-controlled randomized trial of adjunctive light therapy for non-seasonal depression
Chojnacka, M., Antosik-Wójcińska, A. Z., Dominiak, M., Bzinkowska, D., Borzym, A., Sokół-Szawłowska, M., Bodzak-Opolska, G., Antoniak, D., & Święcicki, Ł. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.05.062 · Cited by 32 · see citing works
Duncan, W. C., Johnson, K. A., & Wehr, T. A. (1998) · Journal of Biological Rhythms · doi:10.1177/074873098129000165 · Cited by 20 · see citing works
Geoffroy, P. A., Abbassi, E. M. B. E., Maruani, J., Etain, B., Lejoyeux, M., Amad, A., Courtet, P., Dubertret, C., Gorwood, P., Vaiva, G., et al. (2018) · Psychiatry Investigation · doi:10.30773/pi.2018.09.27.1 · Cited by 16 · see citing works
- Authors
- Deltito, J. A., Moline, M., Pollak, C., Martin, L. Y., & Maremmani, I.
- Affiliations
- University of Pisa (IT)
- Corresponding author
- Deltito, Joseph A.
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 1991-12
- Volume
- 23
- Issue
- 4
- Pages
- 231-237
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2122094422
- Cited by
- 72
- References
- 1
- Citations by year
- 2026: 1 · 2024: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 2 · 2013: 6 · 2012: 5
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- phototherapy, bright light therapy, bipolar depression, major depressive disorder, non-seasonal depression, light intensity, treatment response, bipolar spectrum disorders, depressive symptoms
- MeSH terms
- Bipolar Disorder, Depressive Disorder, Humans, Personality Inventory, Phototherapy, Psychometrics, Seasonal Affective Disorder
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
