Childhood psychopathology retrospectively assessed among adults with early onset major depression
Abstract
Prevalence and impact of comorbidity in early onset major depressive disorder were studied in 116 depressed adult outpatients whose onset of first major depressive episode occurred by age 18. Eighty-eight percent of these patients had at least one additional comorbid Axis I lifetime diagnosis including: social phobia (28%), simple phobia (16%), alcohol (17%) and cannabis (13%) abuse/dependence, and bulimia nervosa (8%). Comorbid anxiety disorders preceded the onset of major depression in two-thirds of individuals while comorbid substance abuse/dependence followed the onset of major depression in two-thirds and predicted more frequent occurrences into adulthood. In contrast to frequency of episodes, severity and duration of an index episode of major depression were not influenced by comorbidity.
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Children and adolescents with major depressive disorder are twice as likely to develop an SUD.
“For instance, children and adolescents with major depressive disorder (MDD) are twice as likely to develop an SUD (Alpert et al. 1994).”
From The Impact of Pharmacotherapy of Childhood-Onset Psychiatric Disorders on the Development of Substance Use Disorders (2022) · cites this paper as Alpert et al. 1994
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References 27 · Cited by 60
- Authors
- Alpert, J. E., Maddocks, A., Rosenbaum, J. F., & Fava, M.
- Affiliations
- Massachusetts General Hospital (US)
- Corresponding author
- Alpert, Jonathan E.
- ORCID
- Alpert, Jonathan E.
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 1994-07
- Volume
- 31
- Issue
- 3
- Pages
- 165-171
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2032359340
- Cited by
- 60
- References
- 27
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2014: 3 · 2013: 2 · 2012: 4
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (NIMH R1MH48483-01)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- childhood psychopathology, comorbidities, social anxiety disorder, specific phobia, substance abuse, alcoholism, cannabis use disorder, bulimia nervosa, anxiety disorders, retrospective evaluation
- MeSH terms
- Adolescent, Adult, Anxiety Disorders, Mental Disorders, Child, Child Behavior Disorders, Depressive Disorder, Double-Blind Method, Female, Fluoxetine, Humans, Imipramine, Male, Middle Aged, Personality Development, Phobic Disorders, Recurrence, Retrospective Studies, 1-Naphthylamine, Comorbidity, Selective Serotonin Reuptake Inhibitors, Paroxetine, Sertraline
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