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Cited by 44Schizophrenia research and treatmentTreatment of Major DepressionMental Health and Psychiatry

Low dose fluphenazine decanoate in maintenance treatment of schizophrenia

Kane, John M., Rifkin, Arthur, Quitkin, Frederic, Nayak, Devdutt, Saraf, Kishore, Ramos-Lorenzi, Jorge R., Klein, Donald F., Sachar, Edward J.·1979·Psychiatry Research
DOI 10.1016/0165-1781(79)90016-7
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Abstract

To test the clinical efficacy of low dose fluphenazine decanoate (1.25 mg to 5.0 mg biweekly), we carried out two separate experiments: (1) an open trial in 57 schizophrenic outpatients, lasting 6 months; (2) a double-blind, placebo-controlled discontinuation study in a subgroup of patients who maintained good remission throughout the entire 6-month open trial. The results suggest that lower doses of fluphenazine decanoate than those usually used may be effective in preventing psychotic relapse while keeping total cumulative dosage to a minimum.

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Crossref · 10.1016/0165-1781(79)90016-7

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References 26 · Cited by 44

Authors
Kane, J. M., Rifkin, A., Quitkin, F., Nayak, D., Saraf, K., Ramos-Lorenzi, J. R., Klein, D. F., & Sachar, E. J.
Affiliations
  • Long Island Jewish Medical Center (US)
  • Mount Sinai Health System (US)
  • New York State Psychiatric Institute (US)
  • Columbia University Irving Medical Center (US)
Corresponding author
Kane, John M.
ORCID
Kane, John M.
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
1979-12
Volume
1
Issue
3
Pages
341-348
ISSN
0165-1781 (ISSN-L)
DOI
10.1016/0165-1781(79)90016-7
OpenAlex
W2078511558
Cited by
44
References
26
Citations by year
2025: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2016: 1 · 2015: 2 · 2012: 1
FWCI
2.87
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords
fluphenazine decanoate, low-dose antipsychotics, schizophrenia, maintenance therapy, relapse prevention, outpatients
MeSH terms
Aftercare, Dose-Response Relationship, Drug, Double-Blind Method, Fluphenazine, Humans, Recurrence, Schizophrenia

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