Differential timing and sexual dimorphism in the expression of the vasopressin gene in the developing rat brain
Abstract
The ontogeny of vasopressin (VP) gene expression in extrahypothalamic neurons of the bed nucleus of the stria terminalis (BNST) and medial amygdala (MA) was investigated using in situ hybridization. In both the BNST and MA, VP mRNA-positive cell profiles were only detected a few days after birth. In males, VP mRNA-expressing cell profiles appear in the BNST on day 3 and in the MA on day 5. In contrast, hybridization signals could not be detected in the female brain until day 14 in the BNST and day 35 in the MA. Adult VP mRNA levels are attained by day 35 in the BNST and day 60 in the MA for both sexes. From this data, it is apparent that development of the VP system is delayed in females compared to the males. Therefore, these data suggest that the sexual dimorphic pattern in the expression of VP mRNA in these nuclei of the adult brain is evident early in the development process.
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Males have more AVP-expressing cells in the bed nucleus of the stria terminalis and medial amygdala and denser AVP-axonal projections to limbic brain regions, especially to the lateral septum.
“For example, males have more AVP-expressing cells in the bed nucleus of the stria terminalis and medial amygdala and denser AVP-axonal projections to limbic brain regions, especially to the lateral septum (De Vries et al., 1981; Van Leeuwen et al., 1985; Szot and Dorsa, 1993).”
From Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context (2014) · cites this paper as Szot and Dorsa, 1993
The transient peak in BNST AVP mRNA is likely the result of activation from the neonatal surge in testosterone that occurs around birth.
“this transient peak in BNST AVP mRNA is likely the result of activation from the neonatal surge in testosterone that occurs around birth (Szot and Dorsa, 1993 and references therein).”
From Sexually dimorphic role for vasopressin in the development of social play (2014) · cites this paper as Szot and Dorsa, 1993
Szot and Dorsa (1993) reported a similar decline in BNST AVP mRNA at 21 days of age from peak levels occurring around 7-14 days of age.
“Szot and Dorsa (1993) reported a similar decline in BNST AVP mRNA at 21 days of age from peak levels occurring around 7–14 days of age.”
From Sexually dimorphic role for vasopressin in the development of social play (2014) · cites this paper as Szot and Dorsa, 1993
At the end of the third week of life, BNST AVP mRNA is high in males but virtually undetectable in females.
“At the end of the third week of life, BNST AVP mRNA is high in males, but virtually undetectable in females (present results; Szot and Dorsa, 1993).”
From Sexually dimorphic role for vasopressin in the development of social play (2014) · cites this paper as Szot and Dorsa, 1993
Compared to females, males have more AVP-expressing cells in the BNST and MeA and denser AVP-axonal projections to limbic brain regions, especially the lateral septum.
“For example, compared to females, males have more AVP-expressing cells in the bed nucleus of the stria terminalis (BNST) and medial amygdala (MeA) and denser AVP-axonal projections to limbic brain regions, especially to the lateral septum (LS) (De Vries et al 1981; van Leeuwen et al., 1985; Szot & Dorsa, 1993).”
From Sex-specific modulation of juvenile social play by vasopressin (2013) · cites this paper as Szot & Dorsa, 1993
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References 34 · Cited by 65
- Authors
- Szot, P., & Dorsa, D. M.
- Affiliations
- University of Washington (US)
- Corresponding author
- Szot, Patricia
- ORCID
- Szot, Patricia
- Venue
- Developmental Brain Research
- Publisher
- Elsevier BV
- Published
- 1993-06
- Volume
- 73
- Issue
- 2
- Pages
- 177-183
- ISSN
- 0165-3806 (ISSN-L)
- OpenAlex
- W2086646313
- Cited by
- 65
- References
- 34
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 6 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 2
- FWCI
- 5.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministerul Cercetării, Inovării şi Digitalizării
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- vasopressin, sexual dimorphism, brain development, bed nucleus of the stria terminalis, medial amygdala, postnatal development
- MeSH terms
- Amygdala, Animals, Autoradiography, Brain, Brain Chemistry, Female, Gestational Age, Image Processing, Computer-Assisted, Male, Oligonucleotides, Pregnancy, Sex Characteristics, Sulfur Radioisotopes, Thalamic Nuclei, Vasopressins, DNA Probes, Gene Expression, In Situ Hybridization, Rats
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